tag:blogger.com,1999:blog-21275046609815603272024-03-19T12:55:39.056+09:00小室一成グループ 論文疑惑東京大学大学院医学系研究科循環器内科学の小室一成教授(元千葉大学、大阪大学)の研究室が発表した論文に関する疑惑についてのまとめブログ。
疑惑1: 不適切な複製実験画像について。
疑惑2: 小室一成教授が代表を務めた降圧薬バルサルタン(ディオバン)の臨床研究VARTに、ノバルティスファーマ社の白橋伸雄氏が身分を隠蔽して統計解析に関与していたことが判明しています。組織ぐるみの詐欺的販売促進活動か?11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.comBlogger15125tag:blogger.com,1999:blog-2127504660981560327.post-54915702409013327872013-05-12T19:09:00.000+09:002014-04-22T22:43:41.934+09:00東京大学大学院医学系研究科循環器内科学<span style="font-size: large;">・ <a href="http://komuroissei.blogspot.com/2013/05/blog-post_7.html">小室一成氏の経歴</a>(千葉大、大阪大学、東京大学教授)</span><br />
<span style="font-size: large;">・ <a href="http://komuroissei.blogspot.com/2013/05/blog-post_6.html">疑惑論文に関連する公的研究費、競争的資金まとめ</a></span><br />
<span style="font-size: large;">・ <a href="http://diovan-novartis.blogspot.com/">ノバルティス社ディオバン臨床研究(VART)に関する疑惑</a></span><span style="font-size: large;">(利益相反問題の隠蔽)</span><br />
<br />
<b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">・電気泳動実験画像や組織画像の不適切利用が疑われている論文</span></b><br />
<a href="http://komuroissei.blogspot.com/2013/05/complement-c1q-activates-canonical-wnt.html">Cell. 2012 Jun 8;149(6):1298-313.</a><br />
<a href="http://komuroissei.blogspot.com/2013/05/igfbp-4-is-inhibitor-of-canonical-wnt.html">Nature. 2008;454:345-9.</a><br />
<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004;279:11384-91.</a><br />
<a href="http://komuroissei.blogspot.com/2013/05/atrial-natriuretic-peptide-inhibits.html">Biochem Biophys Res Commun. 2004;322:310-9.</a><br />
<a href="http://komuroissei.blogspot.com/2013/05/mechanical-stress-activates-angiotensin.html">Nat Cell Biol. 2004;6:499-506.</a><br />
<a href="http://komuroissei.blogspot.com/2013/05/heat-shock-transcription-factor-1.html">Circulation. 2003;108:3024-30.</a><br />
<a href="http://komuroissei.blogspot.com/2013/05/peroxisome-proliferator-activated.html">Circulation. 2002;105:1240-6.</a><br />
<a href="http://komuroissei.blogspot.com/2013/05/context-dependent-transcriptional.html">J Biol Chem. 1999;274:8231-9.</a><br />
<a href="http://komuroissei.blogspot.com/2013/05/detection-of-experimental-autoimmune.html">Circulation. 2002;106:1397-402.</a><br />
<br />
<b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">・CTスキャン画像の不適切利用が疑われている論文</span></b><br />
<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009;15:1082-7.</a><br />
<br />
<b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">・不注意による画像取り違えの可能性もある論文</span></b><br />
<a href="http://komuroissei.blogspot.com/2013/05/mitochondrial-dna-that-escapes-from.html">Nature. 2012;485:251-5.</a>(データの改ざん疑惑を晴らすために生データのチェックが必要)<br />
<a href="http://komuroissei.blogspot.com/2013/05/patients-with-cd36-deficiency-are.html">J Atheroscler Thromb. 2012;19:263-75.</a> (予想通り、不注意による画像取り違えであることが判明。編集側のミスとのことで、<a href="https://www.jstage.jst.go.jp/article/jat/20/5/20_E-10603/_pdf">訂正(Erratum)</a>が出されました。 )<br />
<br />
<b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">・</span></b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><b>ノバルティス社降圧薬バルサルタンの臨床研究(VART)に関する</b></span><span style="font-size: large;"><b><span style="color: red;">利益相反問題の隠蔽</span></b></span><br />
元阪大教授の小室一成氏が代表の<a href="http://diovan-novartis.blogspot.com/2013/05/vart.html">VART試験</a>の主要論文(Hypertens Res. 2011;34:62-9.)とサブ解析論文(J Hum Hypertens. 2012;26:656-63.)の両方にノバルティスファーマ社員の白橋伸雄氏が身分を隠して統計解析に関与していたことが記載されている。<br />
<br />
<b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">・メディアによる報道</span></b><br />
2013年5月10日 Forbes誌: <a href="http://www.forbes.com/sites/larryhusten/2013/05/10/suspicions-raised-about-another-japanese-cardiovascular-researcher/">Suspicions Raised About Another Japanese Cardiovascular Researcher</a> (<a href="http://megalodon.jp/2013-0512-2343-28/www.forbes.com/sites/larryhusten/2013/05/10/suspicions-raised-about-another-japanese-cardiovascular-researcher/">魚拓</a>)<br />
2013年5月17日 フライデー(Friday): <a href="http://blog.goo.ne.jp/lemon-stoism/e/816f2ea1c4c379774044dd01a8e078c8">天皇の主治医 東大教授が「疑惑の人気降圧剤バルサルタン」を大宣伝した</a><br />
2013年5月21日 朝日新聞:<a href="http://diovan-novartis.blogspot.com/2013/04/blog-post_6635.html">臨床研究に製薬会社関与か 千葉大でも高血圧論文調査へ</a><br />
2013年5月25日 フライデー(Friday): <a href="http://diovan-novartis.blogspot.com/2013/04/blog-post_1269.html">【クスリの闇第3弾!】 千葉大も調査へ 「疑惑の降圧剤《ノバルティスファーマ社バルサルタン》」を日経専門誌でPRする教授たちの厚顔</a><br />
<br />
<b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">・類似実験画像が掲載されている疑惑論文の全リスト</span></b>
<br />
<div>
Cell. 2012 Jun 8;149(6):1298-313.<br />
<a href="http://komuroissei.blogspot.com/2013/05/complement-c1q-activates-canonical-wnt.html">Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.</a><br />
責任著者:小室一成<br />
<br />
Nature. 2012 May 10;485(7397):251-5.</div>
<div>
<a href="http://komuroissei.blogspot.com/2013/05/mitochondrial-dna-that-escapes-from.html">Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.</a></div>
<div>
責任著者:大津欣也 (小室一成氏は共著者)<br />
<div>
<br /></div>
</div>
<div>
J Atheroscler Thromb. 2012;19(3):263-75.</div>
<div>
<a href="http://komuroissei.blogspot.com/2013/05/patients-with-cd36-deficiency-are.html">Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases.</a></div>
<div>
責任著者:山下静也 (小室一成氏は共著者)<br />
<div>
<br /></div>
</div>
<div>
Nat Med. 2009 Sep;15(9):1082-7.</div>
<div>
<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">A crucial role for adipose tissue p53 in the regulation of insulin resistance.</a></div>
<div>
責任著者:小室一成<br />
<div>
<br /></div>
</div>
論文#5 Nature. 2008 Jul 17;454(7202):345-9.<br />
<a href="http://komuroissei.blogspot.com/2013/05/igfbp-4-is-inhibitor-of-canonical-wnt.html">IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.</a><br />
責任著者:小室一成<br />
<br />
J Biol Chem. 2004 Mar 19;279(12):11384-91.<br />
<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes.</a><br />
責任著者:小室一成<br />
<br />
Biochem Biophys Res Commun. 2004 Sep 10;322(1):310-9.<br />
<a href="http://komuroissei.blogspot.com/2013/05/atrial-natriuretic-peptide-inhibits.html">Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1.</a><br />
責任著者:小室一成<br />
<br />
Nat Cell Biol. 2004 Jun;6(6):499-506.<br />
<a href="http://komuroissei.blogspot.com/2013/05/mechanical-stress-activates-angiotensin.html">Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.</a><br />
責任著者:小室一成<br />
<br />
Circulation. 2003 Dec 16;108(24):3024-30.<br />
<a href="http://komuroissei.blogspot.com/2013/05/heat-shock-transcription-factor-1.html">Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury.</a><br />
責任著者:小室一成<br />
<div>
<br /></div>
Circulation. 2002 Mar 12;105(10):1240-6.<br />
<a href="http://komuroissei.blogspot.com/2013/05/peroxisome-proliferator-activated.html">Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.</a><br />
責任著者:小室一成<br />
<br />
J Biol Chem. 1999 Mar 19;274(12):8231-9.<br />
<a href="http://komuroissei.blogspot.com/2013/05/context-dependent-transcriptional.html">Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.</a><br />
責任著者:小室一成<br />
<br />
Circulation. 2002 Sep 10;106(11):1397-402.<br />
<a href="http://komuroissei.blogspot.com/2013/05/detection-of-experimental-autoimmune.html">Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C.</a><br />
<div>
責任著者:吉田勝哉</div>
<div>
<br /></div>
<br />
<br />
<b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">・VART論文が訂正される</span></b><br />
<div class="js-tweet-text tweet-text" style="background-color: white; color: #333333; font-family: Georgia, 'Times New Roman', serif; font-size: 22px; line-height: 28px; white-space: pre-wrap; word-wrap: break-word;">
<div class="content clearfix" style="font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px; white-space: normal;">
<div class="permalink-header" style="height: 48px; margin-bottom: 15px;">
<a class="account-group js-account-group js-action-profile js-user-profile-link js-nav" data-user-id="80130924" href="https://twitter.com/JuuichiJigen" style="color: #0084b4; float: left; text-decoration: none;"><br /></a>
<br />
<div class="stream-item-header" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px;">
<a class="account-group js-account-group js-action-profile js-user-profile-link js-nav" data-user-id="80130924" href="https://twitter.com/JuuichiJigen" style="color: #999999; text-decoration: none;"><img alt="論文捏造&研究不正" class="avatar js-action-profile-avatar" src="https://si0.twimg.com/profile_images/3701289691/a38d3a57bff96509edda6c1af43f8eda_normal.jpeg" style="border-bottom-left-radius: 5px; border-bottom-right-radius: 5px; border-top-left-radius: 5px; border-top-right-radius: 5px; border: 0px; float: left; height: 48px; margin-left: -58px; margin-top: 3px; width: 48px;" /><strong class="fullname js-action-profile-name show-popup-with-id" style="color: #333333;">論文捏造&研究不正</strong> <span class="username js-action-profile-name" style="direction: ltr; font-size: 12px; unicode-bidi: embed;"><span style="color: #bbbbbb;">@</span>JuuichiJigen</span></a><small class="time" style="color: #bbbbbb; float: right; font-size: 12px; margin-top: 1px; position: relative;"><a class="tweet-timestamp js-permalink js-nav" href="https://twitter.com/JuuichiJigen/status/340776181462884352" style="color: #999999; font-size: 12px; text-decoration: none;" title="2013年6月1日 - 19:25">6分</a></small></div>
<a class="account-group js-account-group js-action-profile js-user-profile-link js-nav" data-user-id="80130924" href="https://twitter.com/JuuichiJigen" style="color: #0084b4; float: left; text-decoration: none;"></a><br />
<div class="js-tweet-text tweet-text" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px; white-space: pre-wrap; word-wrap: break-word;">
元千葉大の小室一成教授らが論文内容を訂正。訂正は、降圧薬ディオバンの臨床研究VARTの論文におけるノバルティス社員の白橋伸雄の所属隠蔽に関して。 誰が所属隠蔽を指示したかは不明のまま。
<a class="twitter-timeline-link" data-expanded-url="http://diovan-novartis.blogspot.com/2013/05/vart.html" dir="ltr" href="http://t.co/iejZWlEtVM" rel="nofollow" style="color: #0084b4; text-decoration: none;" target="_blank" title="http://diovan-novartis.blogspot.com/2013/05/vart.html"><span class="invisible" style="font-size: 0px; line-height: 0;">http://</span><span class="js-display-url">diovan-novartis.blogspot.com/2013/05/vart.h</span><span class="invisible" style="font-size: 0px; line-height: 0;">tml</span><span class="tco-ellipsis"><span class="invisible" style="font-size: 0px; line-height: 0;"> </span>…</span></a>
<a class="twitter-timeline-link" data-expanded-url="http://www.nature.com/hr/journal/vaop/ncurrent/full/hr201354a.html" dir="ltr" href="http://t.co/5JXM8pRgaJ" rel="nofollow" style="color: #0084b4; text-decoration: none;" target="_blank" title="http://www.nature.com/hr/journal/vaop/ncurrent/full/hr201354a.html"><span class="invisible" style="color: #0084b4; font-size: 0px; line-height: 0; text-decoration: none;">http://www.</span><span class="js-display-url" style="color: #0084b4; text-decoration: none;">nature.com/hr/journal/vao</span><span class="invisible" style="color: #0084b4; font-size: 0px; line-height: 0; text-decoration: none;">p/ncurrent/full/hr201354a.html</span><span class="tco-ellipsis" style="color: #0084b4; text-decoration: none;"><span class="invisible" style="font-size: 0px; line-height: 0;"> </span>…</span></a></div>
<div class="js-tweet-text tweet-text" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px; white-space: pre-wrap; word-wrap: break-word;">
<br /></div>
<div class="js-tweet-text tweet-text" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px; white-space: pre-wrap; word-wrap: break-word;">
<br /></div>
<div class="js-tweet-text tweet-text" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px; white-space: pre-wrap; word-wrap: break-word;">
<br /></div>
<div class="js-tweet-text tweet-text" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px; white-space: pre-wrap; word-wrap: break-word;">
<br /></div>
<div class="js-tweet-text tweet-text" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px; white-space: pre-wrap; word-wrap: break-word;">
<br /></div>
</div>
</div>
<div class="permalink-footer" style="font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; white-space: normal;">
<div class="js-tweet-details-fixer tweet-details-fixer">
<div class="client-and-actions" style="clear: both; margin-top: 10px; overflow: hidden;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:25"><br /></span></span></div>
</div>
</div>
</div>
<div class="permalink-footer" style="background-color: white; color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px;">
<div class="js-tweet-details-fixer tweet-details-fixer">
<br />
<br />
<br />
<div class="permalink-footer" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px;">
<div class="js-tweet-details-fixer tweet-details-fixer">
<blockquote class="tr_bq">
<h1 class="page-header" style="border-bottom-color: rgb(234, 234, 234); border-bottom-style: solid; border-bottom-width: 1px; font-size: 17.27272605895996px; margin: 0px 0px 10px; padding-bottom: 4px; padding-top: 0px;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17">Corrigendum</span></span></h1>
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17"></span></span><br />
<div id="cite" style="font-size: 10px;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17"><i>Hypertension Research</i> advance online publication 23 May 2013; doi: 10.1038/hr.2013.54</span></span></div>
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17"></span></span><br />
<h2 id="atl" style="font-size: 19.09090805053711px; font-weight: normal;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17">Effects of valsartan and amlodipine on cardiorenal protection in Japanese hypertensive patients: the Valsartan Amlodipine Randomized Trial</span></span></h2>
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17"></span></span><br />
<div id="aug" style="font-size: 12.727272033691406px;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17">Hiroya Narumi, Hiroyuki Takano, Satoshi Shindo, Miwa Fujita, Hiroshi Mizuma, Yoichi Kuwabara and Issei Komuro on behalf of the VART Investigators</span></span></div>
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17"></span></span><br />
<div id="articlebody" style="padding-bottom: 1.5em;">
<div class="norm" style="color: black; font-family: Verdana, arial, Helvetica, sans-serif; font-size: 12.727272033691406px; line-height: normal; margin-bottom: 1em; margin-top: 1em;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17"><b>Correction to</b>: <i>Hypertension Research</i> (2011) <b>34</b>, 62–69; doi:<a href="http://www.nature.com/doifinder/10.1038/hr.2010.186" style="color: #663399;">10.1038/hr.2010.186</a>; published online 7 October 2010</span></span></div>
<div class="norm" style="color: black; font-family: Verdana, arial, Helvetica, sans-serif; font-size: 12.727272033691406px; line-height: normal; margin-bottom: 1em; margin-top: 1em;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17">The authors of the manuscript would like to correct affiliation of Mr Nobuo Shirahashi, who was mentioned in the acknowledgement section of this article. The correct affiliation of Mr Shirahashi was Novartis Pharma K.K.</span></span></div>
</div>
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年6月1日 - 19:17">
</span></span></blockquote>
</div>
</div>
<div style="color: black; font-family: 'MS PGothic'; font-size: medium; line-height: normal;">
</div>
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-24350818655320165682013-05-10T19:00:00.000+09:002013-05-10T15:53:20.102+09:00経歴<span style="color: red; font-size: x-large;"><b>・ 小室一成教授の経歴</b></span><br />
<span style="font-size: x-large;"><b><br /></b></span>
<span style="font-size: x-large;"><b>氏名: 小室一成 <a href="http://isseikomuro.blogspot.com/">KOMURO Issei</a></b></span><br />
<br />
<ul style="background-color: white; color: #333333; font-size: 16px; margin: 0px 0px 0px 1.5em; padding: 0px;"><div style="color: #333333; font-size: 16px;">
</div>
</ul>
<br />
<br />
<div style="color: #333333; font-size: 16px;">
<b style="background-color: #b6d7a8; font-size: xx-large;">学歴</b></div>
東京大学 医学系研究科 修了: 1982年03月<br />
<br />
<br />
<div class="text" style="background-color: white; margin: 0px; padding: 0px 0px 20px;">
<div id="item_shokurk_div_minus" style="margin: 0px; padding: 0px;">
<div style="color: #333333; font-size: 16px;">
<b style="background-color: #b6d7a8; font-size: xx-large;">職歴</b></div>
</div>
<span style="background-color: #b6d7a8;"></span>
<br />
<div style="display: inline !important;">
東京大学医学部附属病院医員 1982年06月 ~ 1989年08月<span class="Apple-tab-span" style="white-space: pre;"> </span></div>
米国Harvard大学医学部 1989年09月 ~ 1993年09月<span class="Apple-tab-span" style="white-space: pre;"> </span><br />
東京大学医学部附属病院助手 1993年11月 ~ 1998年05月<span class="Apple-tab-span" style="white-space: pre;"> </span><br />
東京大学大学院医学系研究科循環器内科学講師 1998年05月 ~ 2000年09月<span class="Apple-tab-span" style="white-space: pre;"> </span><br />
千葉大学大学院医学研究院循環病態医科学循教授 2000年10月 ~ 2001年03月<span class="Apple-tab-span" style="white-space: pre;"> </span><br />
千葉大学大学院医学研究院循環病態医科学教授 2001年04月 ~ 2010年03月<span class="Apple-tab-span" style="white-space: pre;"> </span><br />
大阪大学大学院医学系研究科循環器内科学教授 2010年04月 ~ 継続中
<br />
2010年04月01日 ~ 2011年03月31日,医学系研究科 内科系臨床医学専攻,教授,専任<br />
2011年04月01日 ~ 2012年12月31日,医学系研究科 医学専攻,教授,専任<br />
2013年01月01日 ~ 継続中,大阪大学未来戦略機構,特任教授,専任
<br />
東京大学大学院医学系研究科循環器内科学教授 2013年01月01日 ~ 継続中<br />
<br />
<br />
<div style="color: #333333; font-size: 16px;">
<b style="background-color: #b6d7a8; font-size: xx-large;">所属学会</b></div>
</div>
<div id="item_shokurk_div_minus" style="color: #333333; font-size: 16px; margin: 0px; padding: 0px;">
</div>
<div id="item_shokurk_div_minus" style="color: #333333; font-size: 16px; margin: 0px; padding: 0px;">
<ol start="1" style="color: black; font-size: 14px; margin: 0px 20px 0px 40px; padding: 0px;">
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
アメリカ心臓協会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
国際心臓研究学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
東京医学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本老年医学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本心臓核医学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本脈管学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本臨床生理学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本再生医療学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本成人病(生活習慣病)学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本心臓病学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本分子生物学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本臨床分子医学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本心不全学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本適応医学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本心血管内分泌代謝学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本高血圧学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本内科学会</div>
</li>
<li style="margin: 0px 0px 10px; padding: 0px;"><div class="title" style="padding: 0px;">
日本循環器学会</div>
<div class="title" style="padding: 0px;">
<br /></div>
<div class="title" style="padding: 0px;">
<br /></div>
</li>
</ol>
</div>11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-27566564693734818942013-05-10T18:00:00.000+09:002014-04-22T22:41:34.128+09:00疑惑論文に関連する公的研究費、競争的資金まとめ<br />
<big><b><span style="color: red; font-size: small;">公的研究費1</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
基盤研究(B)、総額:18200千円、研究代表者:南野徹(千葉大学・大学院・医学研究院・講師)
<br />
細胞老化・個体老化シグナル制御による心血管治療法の開発に関する基盤研究<br />
<a href="http://kaken.nii.ac.jp/d/p/21390237">研究課題番号:21390237</a><br />
<a href="http://kaken.nii.ac.jp/d/p/21390237/2009/3/ja.ja.html">2009年度 研究実績報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>が記載されている。<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費2</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
基盤研究(S)、総額:179530千円、研究代表者:<a href="http://komuroissei.blogspot.com/">小室一成</a>(大阪大学・医学(系)研究科(研究院)・教授)<br />
Wntシグナルによる心筋分化・心臓疾患発症機序の解明とそれに基づく治療法の開発<br />
<a href="http://kaken.nii.ac.jp/d/p/21229010">研究課題番号:21229010</a><br />
<a href="http://kaken.nii.ac.jp/d/p/21229010/2009/3/ja.ja.html">2009年度 研究実績報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>が記載されている。<br />
また、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/igfbp-4-is-inhibitor-of-canonical-wnt.html">Nature. 2008 Jul 17;454(7202):345-9.</a>に関連が深い課題内容であり、この公的研究費の獲得申請の業績として疑惑論文が利用された可能性が推測される。
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費3</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
基盤研究(B)、総額:13520千円、研究代表者:石川冬木(京都大学・大学院・生命科学研究科・教授)
<br />
細胞老化における核・クロマチン機能<br />
<a href="http://kaken.nii.ac.jp/d/p/20370079.ja.html">研究課題番号:20370079</a><br />
<a href="http://kaken.nii.ac.jp/d/p/20370079/2009/8/ja.ja.html">2009年度 研究成果報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>が記載されている。<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費4</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
基盤研究(C)、総額:3400千円、
研究代表者:永井 敏雄(千葉大学・医学部附属病院・講師)、研究分担者:<a href="http://komuroissei.blogspot.com/">小室一成</a>(千葉大学・大学院・医学研究院・教授)
<br />
骨格筋由来の心筋前駆細胞の同定と心筋再生医療への応用<br />
<a href="https://kaken.nii.ac.jp/d/p/15590720.ja.html">研究課題番号:15590720</a><br />
<a href="https://kaken.nii.ac.jp/d/p/15590720/2004/3/ja.ja.html">2004年度 研究成果報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a>と<a href="http://komuroissei.blogspot.com/2013/05/heat-shock-transcription-factor-1.html">Circulation. 2003 Dec 16;108(24):3024-30.</a>が記載されている。<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費5</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
基盤研究(B)、総額:12400千円、研究代表者:門前 幸志郎(東京大学・医学部附属病院・助手)
<br />
幹細胞を用いた効率的な心筋細胞分化誘導法の開発と心不全に対する細胞移植治療の試み<br />
Development of the way how to induce efficient cardiomyocyte differentiation using stem cells and attempt for cell transplantation therapy against heart failure<br />
<a href="http://kaken.nii.ac.jp/d/p/15390242.ja.html">研究課題番号:15390242</a><br />
<a href="http://kaken.nii.ac.jp/d/p/15390242/2004/3/ja.ja.html">2004年度 研究実績報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">Biochem Biophys Res Commun. 2004 Sep 10;322(1):310-9.</a>が記載されている。<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費6</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
特定領域研究、総額:3900千円、研究代表者:中井 彰(山口大学・大学院・医学研究科・教授)
<br />
熱ショック転写因子群による細胞分化と死のシグナル制御<br />
<a href="http://kaken.nii.ac.jp/d/p/15024248">研究課題番号:15024248</a><br />
<a href="http://kaken.nii.ac.jp/d/p/15024248/2003/3/ja.ja.html">2003年度 研究成果報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/heat-shock-transcription-factor-1.html">Circulation. 2003 Dec 16;108(24):3024-30.</a>が記載されている。<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費7</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
若手研究(B)、総額:4800千円、研究代表者:赤澤 純代(金沢医科大学・医学部・助手)
<br />
心筋梗塞の新しい治療法の開発-体性幹細胞を用いた再生治療<br />
<a href="https://kaken.nii.ac.jp/d/p/14770336.ja.html">研究課題番号:14770336</a><br />
<a href="http://kaken.nii.ac.jp/d/p/14770336/2004/3/ja.ja.html">2004年度 研究実績報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">Biochem Biophys Res Commun. 2004 Sep 10;322(1):310-9.</a>と<a href="http://komuroissei.blogspot.com/2013/05/mechanical-stress-activates-angiotensin.html">Nat Cell Biol. 2004 Jun;6(6):499-506.</a>が記載されている。<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費8</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
基盤研究(C)、総額:4000千円、研究代表者:高野 博之(千葉大学・大学院・医学研究院・助手)、研究分担者:<a href="http://komuroissei.blogspot.com/">小室一成</a>(千葉大学・大学院・医学研究院・教授)
<br />
心肥大および心不全の病態形成におけるPPARγの役割の解析<br />
ROLES OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ IN CARDIOVASCULAR DISEASE<br />
<a href="http://kaken.nii.ac.jp/d/p/14570638">研究課題番号:14570638</a><br />
<a href="http://kaken.nii.ac.jp/d/p/14570638/2003/3/ja.ja.html">2003年度 研究成果報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/heat-shock-transcription-factor-1.html">Circulation. 2003 Dec 16;108(24):3024-30.</a>と<a href="http://komuroissei.blogspot.com/2013/05/peroxisome-proliferator-activated.html">Circulation. 2002 Mar 12;105(10):1240-6.</a>が記載されている。<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費9</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
特定領域研究(B)→特定領域研究、総額:142400千円、研究代表者:<a href="http://komuroissei.blogspot.com/">小室一成</a>(千葉大学・大学院・医学研究院・教授)
<br />
細胞分化による心不全の遺伝子治療<br />
<a href="http://kaken.nii.ac.jp/d/p/12136201">研究課題番号:12136201</a><br />
<a href="http://kaken.nii.ac.jp/d/p/12136201/2003/3/ja.ja.html">2003年度 研究実績報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/heat-shock-transcription-factor-1.html">Circulation. 2003 Dec 16;108(24):3024-30.</a>が記載されている。<br />
さらに、<a href="http://kaken.nii.ac.jp/d/p/12136201/2004/3/ja.ja.html">2004年度 研究実績報告書</a>に、疑惑論文の
<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a>が記載されている。<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費10</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
特定領域研究、総額:33300千円、研究代表者:<a href="http://komuroissei.blogspot.com/">小室一成</a>(千葉大学・大学院・医学研究院・教授)
<br />
心不全の戦略的研究―発生工学を用いた心不全の病態解明と遺伝子・細胞治療<br />
<a href="http://kaken.nii.ac.jp/d/p/12136101">研究課題番号:12136101</a><br />
<a href="http://kaken.nii.ac.jp/d/p/12136101/2003/3/ja.ja.html">2003年度 研究実績報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/heat-shock-transcription-factor-1.html">Circulation. 2003 Dec 16;108(24):3024-30.</a>が記載されている。<br />
さらに、<a href="http://kaken.nii.ac.jp/d/p/12136101/2004/3/ja.ja.html">2004年度 研究実績報告書</a>に、疑惑論文の
<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a>が記載されている。<br />
<br />
<br />
<br />
<big><b><span style="color: red; font-size: small;">公的研究費11</span></b></big><br />
<b>科学研究費(文部科学省、日本学術振興会)</b><br />
特別推進研究、総額:278000千円、研究代表者:矢崎義雄(東京大学・医学部・附属病院・教授)
<br />
研究分担者:<a href="http://komuroissei.blogspot.com/">小室一成</a>(千葉大学・医学部・教授)ら<br />
心血管系の発生分化とその分子機構の解析<br />
<a href="http://kaken.nii.ac.jp/d/p/09102005">研究課題番号:09102005</a><br />
<a href="http://kaken.nii.ac.jp/d/p/09102005/1998/3/ja.ja.html">1998年度 研究実績報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/rho-family-small-g-proteins-play.html">Circ Res. 1999 Mar 5;84(4):458-66.</a>が記載されている。<br />
さらに、<a href="http://kaken.nii.ac.jp/d/p/09102005/1999/3/ja.ja.html">1999年度 研究実績報告書</a>に、疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/context-dependent-transcriptional.html">J Biol Chem. 1999 Mar 19;274(12):8231-9.</a>が記載されている。<br />
<span style="font-size: small;"><big><b><span style="color: red;"><br /></span></b></big><b><span style="color: red;">公的研究費12</span></b></span><br />
<big><span style="font-size: small;"><b>厚生労働科学研究費補助金 (the Ministry of Health, Labour, and Welfare)</b></span></big><br />
<big><span style="font-size: small;">疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/igfbp-4-is-inhibitor-of-canonical-wnt.html">Nature. 2008 Jul 17;454(7202):345-9.</a>の本文中に、当研究費を使用したことが記載されている。 </span></big><br />
<br />
<span style="font-size: small;"><big><b><span style="color: red;"><br /></span></b></big><b><span style="color: red;">公的研究費13</span></b></span><br />
<big><span style="font-size: small;"><b>Welfare, and the New Energy and</b></span></big><br />
<big><span style="font-size: small;"><b>Industrial Technology Development Organization (NEDO).</b></span></big><br />
<big><span style="font-size: small;">疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/igfbp-4-is-inhibitor-of-canonical-wnt.html">Nature. 2008 Jul 17;454(7202):345-9.</a>の本文中に、当研究費を使用したことが記載されている。 </span></big><br />
<big><span style="font-size: small;"><br /></span></big>
<span style="font-size: small;"><big><b><span style="color: red; font-size: small;">その他競争的資金1</span></b></big></span><br />
<b>the Suzuken Memorial Foundation,</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>の本文中に、当研究費を使用したことが記載されている。<br />
<br />
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金2</span></b><br />
<b>the Japan Diabetes Foundation</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>の本文中に、当研究費を使用したことが記載されている。<br />
<div>
<br /></div>
<div>
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金3</span></b><br />
<b>the Ichiro Kanehara Foundation</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>の本文中に、当研究費を使用したことが記載されている。 </div>
<div>
<br /></div>
<div>
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金4</span></b><br />
<b>the Cell Science </b><b>Research Foundation</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>の本文中に、当研究費を使用したことが記載されている。</div>
<div>
<br /></div>
<div>
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金5</span></b><br />
<b>the Japan Foundation of Applied Enzymology (to T.M.)</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>の本文中に、当研究費を使用したことが記載されている。 </div>
<div>
<br /></div>
<div>
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金6</span></b><br />
<b>the Tokyo Biochemical Research Foundation</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>の本文中に、当研究費を使用したことが記載されている。 </div>
<div>
<br /></div>
<div>
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金7</span></b><br />
<b>the Takeda Science Foundation</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/a-crucial-role-for-adipose-tissue-p53.html">Nat Med. 2009 Sep;15(9):1082-7.</a>の本文中に、当研究費を使用したことが記載されている。 </div>
<div>
<br /></div>
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金8</span></b><br />
<b>Takeda Medical Research Foundation</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a>の本文中に、当研究費を使用したことが記載されている。
<br />
<br />
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金9</span></b><br />
<b>公益財団法人上原記念生命科学財団(Uehara Memorial Foundation)</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/mechanical-stress-activates-angiotensin.html">Nat Cell Biol. 2004 Jun;6(6):499-506.</a> (a grant for research on life science from Uehara Memorial Foundation, Japan (to I.K.))と、 <a href="http://komuroissei.blogspot.com/2013/05/heat-shock-transcription-factor-1.html">Circulation. 2003 Dec 16;108(24):3024-30.</a> (a grant for research on life science from Uehara Memorial Foundation, Japan (to I. Komuro))と、 <a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a>の本文中に、当研究費を使用したことが記載されている。
<br />
<br />
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金10</span></b><br />
<b>日本医師会(grant-in-aid of The Japan Medical Association)</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a>の本文中に、当研究費を使用したことが記載されている。
<br />
<br />
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金11</span></b><br />
<b>公益信託加藤記念難病研究助成基金(The Kato Memorial Trust for Nambyo Research)</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a>の本文中に、当研究費を使用したことが記載されている。
<br />
<br />
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金12</span></b><br />
<b>a Japan Heart Foundation Research Grant (grants from the Japan Heart Foundation) (日本心臓財団研究助成)</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/adult-cardiac-sca-1-positive-cells.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a> と、<a href="http://komuroissei.blogspot.com/2013/05/context-dependent-transcriptional.html">J Biol Chem. 1999 Mar 19;274(12):8231-9.</a>の本文中に、当研究費を使用したことが記載されている。<br />
<br />
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金13</span></b><br />
<b>grants from Yamanouchi Pharmaceuticals</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/context-dependent-transcriptional.html">J Biol Chem. 1999 Mar 19;274(12):8231-9.</a>の本文中に、当研究費を使用したことが記載されている。<br />
<br />
<b><span style="color: red;">その他</span></b><b><span style="color: red;">競争的資金14</span></b><br />
<b>grants from Tanabe Medical Frontier Conference</b><br />
疑惑論文の<a href="http://komuroissei.blogspot.com/2013/05/context-dependent-transcriptional.html">J Biol Chem. 1999 Mar 19;274(12):8231-9.</a>の本文中に、当研究費を使用したことが記載されている。<br />
<br />
<!--2-->11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-71381531744241697692013-05-08T18:11:00.000+09:002013-05-26T18:11:34.772+09:00Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.<span role="menubar" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">疑惑論文#1</span><br />
<span role="menubar" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"><br /></span>
<span role="menubar" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">Cell.</span><span style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"> 2012 Jun 8;149(6):1298-313. doi: 10.1016/j.cell.2012.03.047.</span><br />
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
<span class="highlight">Complement</span> <span class="highlight">C1q</span> <span class="highlight">activates</span> <span class="highlight">canonical</span> <span class="highlight">Wnt</span> <span class="highlight">signaling</span> and <span class="highlight">promotes</span> <span class="highlight">aging-related</span> <span class="highlight">phenotypes</span>.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px;">Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A,Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.</span></span></div>
<div class="aff" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<h3 class="label" style="color: #724128; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan.</div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/22682250">http://www.ncbi.nlm.nih.gov/pubmed/22682250</a></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529917/">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529917/</a></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.cell.com/retrieve/pii/S0092867412005314">http://www.cell.com/retrieve/pii/S0092867412005314</a></div>
</div>
<div class="err" style="background-color: white; line-height: 18.88888931274414px; margin: 1.1em auto 0px;">
<h3 style="font-size: 1.0769em; line-height: 1.2857; margin: 0.5em 0px 0px !important;">
</h3>
<div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 13.333333969116211px;">
<div style="font-family: 'Times New Roman'; font-size: medium;">
<span style="font-family: Arial, Helvetica, sans-serif; font-size: large;">Download - <a href="http://kmb.prf.jcu.cz/userfiles/media/file/03_bryja.pdf">PDF file of the article (<span role="menubar" style="line-height: 19.625px;">Cell.</span><span style="line-height: 19.625px;"> 2012;149:1298-313) before erratum</span></a></span></div>
<div style="font-size: 13.333333969116211px;">
</div>
</div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 13.333333969116211px;">
</div>
</div>
<h3 style="font-size: 1.0769em; line-height: 1.2857; margin: 0.5em 0px 0px !important;">
</h3>
<h3 style="font-size: 1.0769em; line-height: 1.2857; margin: 0.5em 0px 0px !important;">
Erratum in <a href="http://www.cell.com/retrieve/pii/S009286741200877X" style="font-size: 13.333333969116211px; line-height: 18.88888931274414px;">http://www.cell.com/retrieve/pii/S009286741200877X</a></h3>
<div>
<div class="ja50-ce-para" style="line-height: 19.573863983154297px; margin-bottom: 0.8em; margin-top: 0.8em;" xmlns:cja="http://www.elsevier.com/xml/cja/dtd">
<div style="font-family: arial, helvetica, 'Lucida Grande', Tahoma, verdana, sans-serif; font-size: 11.818181991577148px;">
The article above reported a role for complement C1q in promoting age-related phenotypes. Since publication, we have noticed that the upper panels shown in<a class="ja50-ce-cross-ref" href="http://www.cell.com/retrieve/pii/S009286741200877X#fig7" name="back-fig7" style="color: #005587; text-decoration: none;">Figure 7</a>F were incorrectly selected and labeled. The upper-right panel portrayed an image from aged C1qKO mice, not aged wild-type mice treated with M241, as originally labeled. The upper-left panel was correctly labeled as aged wild-type mice treated with PBS, but the magnification of both images in the top panels was incorrectly labeled and did not match the magnification of the bottom two panels. The corrected figure, with the upper-left panel now portraying an image from aged wild-type mice treated with PBS and the upper-right panel portraying an image from aged wild-type mice treated with M241, both taken with a 4× magnification (scale bars, 150 μm), is shown on the following page. We sincerely apologize for these mistakes and emphasize that the correction of these errors does not impact our conclusions</div>
<div style="font-family: arial, helvetica, 'Lucida Grande', Tahoma, verdana, sans-serif; font-size: 11.818181991577148px;">
<br /></div>
<div style="font-family: arial, helvetica, 'Lucida Grande', Tahoma, verdana, sans-serif; font-size: 11.818181991577148px;">
<br /></div>
<div style="font-family: arial, helvetica, 'Lucida Grande', Tahoma, verdana, sans-serif; font-size: 11.818181991577148px;">
<br /></div>
<div class="separator" style="clear: both; font-family: arial, helvetica, 'Lucida Grande', Tahoma, verdana, sans-serif; font-size: 11.818181991577148px; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEislCywN5h2HxEQjIFuhs35i1dV3nJQlzwwEKHXZEqnuLKgr2Uv8Zeu1dXO8yz9rKWCMgBnzsYeRx8UpRnr0wX4fsLht7lDJq6JE0dlD_bW9fZ4UO73Vf3WCFwKBCXcqTWdbXzqWxIh7ero/s1600/cell+2012%E3%81%AE%E3%82%B3%E3%83%94%E3%83%BC.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="317" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEislCywN5h2HxEQjIFuhs35i1dV3nJQlzwwEKHXZEqnuLKgr2Uv8Zeu1dXO8yz9rKWCMgBnzsYeRx8UpRnr0wX4fsLht7lDJq6JE0dlD_bW9fZ4UO73Vf3WCFwKBCXcqTWdbXzqWxIh7ero/s400/cell+2012%E3%81%AE%E3%82%B3%E3%83%94%E3%83%BC.jpg" width="400" /></a></div>
<div class="separator" style="clear: both; text-align: center;">
<span style="font-family: Arial, Helvetica, sans-serif;"><b><br /></b></span></div>
<div class="separator" style="clear: both; text-align: center;">
<span style="background-color: whitesmoke; line-height: 17.99715805053711px; text-align: left; white-space: pre-wrap;"><span style="color: red; font-family: Arial, Helvetica, sans-serif;"><b>不適切に使用されていた実験画像は、サイズ変更だけでなく縦横比も変更されていたことが判明。意図的な改ざんか?という疑惑を晴らすためには生データの確認が必要。</b></span></span></div>
<div class="separator" style="clear: both; font-family: arial, helvetica, 'Lucida Grande', Tahoma, verdana, sans-serif; font-size: 11.818181991577148px; text-align: center;">
<br /></div>
<div class="separator" style="clear: both; font-family: arial, helvetica, 'Lucida Grande', Tahoma, verdana, sans-serif; font-size: 11.818181991577148px; text-align: center;">
<br /></div>
<div style="font-family: arial, helvetica, 'Lucida Grande', Tahoma, verdana, sans-serif; font-size: 11.818181991577148px;">
<br /></div>
</div>
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-85072569546664441962013-05-07T23:46:00.000+09:002013-07-07T02:25:37.644+09:00Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C.<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<span role="menubar">Circulation.</span> 2002 Sep 10;106(11):1397-402.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.666666984558105px;">Sato M, Toyozaki T, Odaka K, Uehara T, Arano Y, Hasegawa H, Yoshida K, Imanaka-Yoshida K, Yoshida T, Hiroe M, Tadokoro H, Irie T, Tanada S,Komuro I.</span></span></div>
<div class="aff" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; line-height: 1.0915em;">
<h3 class="label" style="color: #724128; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="font-size: 0.8465em; margin-bottom: 0.5em; margin-top: 0.5em;">
Department of Cardiovascular Science and Medicine, Graduate School of Medicine, Chiba University, Chiba-shi, Chiba, Japan.</div>
<div style="font-size: 0.8465em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-size: 0.8465em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/12221059">http://www.ncbi.nlm.nih.gov/pubmed/12221059</a></div>
<div style="font-size: 0.8465em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://circ.ahajournals.org/content/106/11/1397.long">http://circ.ahajournals.org/content/106/11/1397.long</a></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="font-size: 0.8465em;">
<a href="http://circ.ahajournals.org/content/106/11/1397.full.pdf+html">http://circ.ahajournals.org/content/106/11/1397.full.pdf+html</a></div>
<div style="font-size: 0.8465em;">
<br /></div>
<div style="font-size: 0.8465em;">
<br /></div>
<span style="color: red;"><br /></span>
<b><span style="color: red;">In figure 3, the image of 3-c is identical to the 165 degrees-clockwise rotated and size-reduced version of the image of 2-c.</span></b><br />
<div style="font-size: 0.8465em;">
<br /></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhmFB1Ym9MQc7GjkVAVie3i_Iu3d5o5jfeNjfop84-X7tnPmcalh6GFMuV05dRuJks-u08TK1naNtrbfjWgbjw8z2Q7lwf8a854b4HBXOa9lUNcB6aNbD-KBEtdWrspwZ3oU2kftkIKKhSk/s1600/Figure3.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="326" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhmFB1Ym9MQc7GjkVAVie3i_Iu3d5o5jfeNjfop84-X7tnPmcalh6GFMuV05dRuJks-u08TK1naNtrbfjWgbjw8z2Q7lwf8a854b4HBXOa9lUNcB6aNbD-KBEtdWrspwZ3oU2kftkIKKhSk/s400/Figure3.jpg" width="400" /></a></div>
<div style="font-size: 0.8465em;">
<br /></div>
<div style="font-size: 0.8465em;">
<br /></div>
<div style="font-size: 0.8465em;">
<br /></div>
<div style="font-size: 0.8465em;">
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">国立大学法人千葉大学学術国際部研究推進課長様 </span></div>
<div style="font-size: medium;">
<span style="color: blue;"><br style="font-family: 'MS PGothic'; line-height: 18px;" /></span><span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">千葉大学大学院医学研究院循環病態医科学グループの研究活動の不正行為の疑惑に関して申立てましたXXXXXXX と申します(平成25年5月30日付けで受理)。 </span></div>
<div style="font-size: medium;">
<span style="color: blue;"><br style="font-family: 'MS PGothic'; line-height: 18px;" /></span><span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">前回送付した申立書において、千葉大学に所属していた小室一成氏らのグループから発表された14報の論文について研究不正の疑義を申立てていましたが、さらに同グループから発表された下記の別の論文1報に関して実験画像の流用(捏造・改ざん)の疑いが見つかりましたのでお知らせいたします。この論文の疑義に関しても調査していただけないでしょうか。論文名および不正疑惑の具体的内容は下記の通りです。このメールに添付した不正疑義の解説図(Figure3.jpg)もご参照ください。 </span></div>
<div style="font-size: medium;">
<span style="color: blue;"><br style="font-family: 'MS PGothic'; line-height: 18px;" /></span><span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">論文名: </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">Circulation. 2002 Sep 10;106(11):1397-402. </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">Sato M, Toyozaki T, Odaka K, Uehara T, Arano Y, Hasegawa H, Yoshida K, Imanaka-Yoshida K, Yoshida T, Hiroe M, Tadokoro H, Irie T, Tanada S,Komuro I. </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">Source </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">Department of Cardiovascular Science and Medicine, Graduate School of Medicine, Chiba University, Chiba-shi, Chiba, Japan. </span></div>
<div style="font-size: medium;">
<span style="color: blue;"><br style="font-family: 'MS PGothic'; line-height: 18px;" /></span><span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">不正疑惑の具体的内容: </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">Figure 3において、2-cの画像を時計回りに165度回転させ、サイズを90%に縮小させたものに、3-cの画像が類似しています。 </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">2-cと3-cの画像は互いに異なる個体から由来するものであるはずですが、互いに類似しているのは極めて不自然です。 </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">これが、不適切な画像流用だとすると、元の画像を回転させたり、サイズを変更したりするなどの操作を加えていることから、意図的に研究不正を働いた可能性が推測されます。2-cの画像は2-aと2-bに輪郭がほとんど一致していることから、2-cの画像がオリジナル画像と推測され、その場合、3-cが流用画像となりますが、つじつまを合わせるために、3-cの輪郭も3-aや3-bの画像の輪郭に近くなるように、画像の回転角度やサイズが調整され流用されています。よって、意図的な不正である可能性が極めて高いと考えれます。 </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;">不正の有無について調査をよろしくお願いいたします。 </span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;"><br /></span></div>
<div style="font-size: medium;">
<span style="color: blue; font-family: 'MS PGothic'; line-height: 18px;"><br /></span></div>
</div>
<div style="font-size: 0.8465em;">
<br />
<div class="content clearfix" style="-webkit-text-stroke-width: 0px; color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 17.98611068725586px; margin-left: 58px; orphans: auto; position: relative; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; word-wrap: break-word;">
</div>
<br /><br /><br /><hr style="-webkit-text-stroke-width: 0px; color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 13.333333015441895px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 14.541666984558105px; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px;" />
</div>
</div>
<h1 style="border-bottom-color: rgb(102, 102, 102); border-bottom-style: dotted; border-bottom-width: 1px; color: #444444; font-family: 'MS Pゴシック', Osaka, serif; font-size: 20px; line-height: normal; margin: 0px; padding: 50px 10px 5px 5px;">
<a href="http://blog.m3.com/flyingmedicords" style="color: #666666;">ブルースin東京/Blues in Tokyo・Yumemi</a> より</h1>
<div style="font-size: 0.8465em;">
<br /></div>
<div style="font-size: 0.8465em;">
<br /></div>
<div class="title" style="color: #444444; font-family: 'MS Pゴシック', Osaka, serif; font-size: 0.8465em; line-height: normal; position: relative;">
<h2 style="border-bottom-color: rgb(102, 102, 102); border-bottom-style: dotted; border-bottom-width: 1px; font-size: 14px; margin: 0px; padding: 7px 5px;">
<a href="http://blog.m3.com/flyingmedicords/20130623/1" style="color: #321800; text-decoration: none;">「あ・・。開いた口が。。。」</a></h2>
<div style="position: absolute; right: 0px; top: 8px;">
<a href="http://blog.m3.com/users/270630/profile" style="color: #b35400;">夢見る掃除人</a> / 2013.06.23 16:36 / 推薦数 : 8</div>
</div>
<div class="body" style="clear: both; color: #444444; font-family: 'MS Pゴシック', Osaka, serif; font-size: 0.8465em; line-height: normal; padding: 5px 15px;">
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 24pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 24pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 24pt;"><span style="color: #3300cc;">「あ・・。</span><span style="color: #ff0099;">開</span><span style="color: #0099cc;">い</span><span style="color: #993300;">た</span><span style="color: #663399;">口</span><span style="color: red;">が</span><span style="color: #cc0099;">。</span><span style="color: #ff9900;">。</span><span style="color: #cc0033;">。</span><span style="color: #000099;">」</span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;">―</span><span style="color: black; font-family: 'Calligraph421 BT'; font-size: 18pt;"> Wow! It sure is jaw-dropping. </span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;">―</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> 先に解析した画像トリックについて、もうちょっと突っ込んでみましょう。</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> ひとつの画像が別の画像に捏り変えることができるということは、その逆も成り立ちます。</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> すなわち、</span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #009900;">3-c</span></span><span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">→</span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #006699;">2-c</span></span><span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">なら、<span style="font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #006699;">2-c</span></span></span><span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">→<span style="font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #009900;">3-c</span></span></span><span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">も成り立つということです。</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><img alt="" border="0" height="375" src="http://blog.m3.com/flyingmedicords/files/Circulation+2002+%28106%29%E3%82%A2%E3%83%B3%E3%82%B3%E3%82%A6%E3%81%9D%E3%81%AE%EF%BC%91%E6%89%8B%E7%9B%B4%E3%81%972Komuro.jpg" style="border: none; height: 375px; width: 500px;" width="500" /> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> 二枚しかなかったら、どっちがどっちかわかります?わからないでしょ。</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> 「こんなことして何になる」と言われるかもしれませんが、捏られた画像の特徴をもっとよく観察してみましょう。</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> 「アングリ開いたアンコウの口」に見えてきませんか</span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;">?</span><span style="color: #ff66ff;"><span style="font-family: Century; font-size: small;"><a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="See? でしょん?"><img alt="実写、動物、かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/04ctj_717328/%E5%AE%9F%E5%86%99%E3%80%81%E5%8B%95%E7%89%A9%E3%80%81%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.GIF" style="border: none;" /></a></span></span><span style="color: #ff66ff;"><span style="font-size: small;"><span style="font-family: Century;"></span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><img alt="" border="0" height="375" src="http://blog.m3.com/flyingmedicords/files/Circulation+2002+%28106%29%E3%82%A2%E3%83%B3%E3%82%B3%E3%82%A6%E3%81%9D%E3%81%AE2Komuro.jpg" style="border: none; height: 375px; width: 500px;" width="500" /> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-family: 'MS Pゴシック'; font-size: 9.5pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-family: 'MS Pゴシック'; font-size: 9.5pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-family: 'MS Pゴシック'; font-size: 9.5pt;"><a href="http://circ.ahajournals.org/content/106/11/1397.full.pdf+html" style="color: #b35400;" target="_blank" title="Circulation 2002 (106) Chiba Paper"><img alt="" border="0" height="375" src="http://blog.m3.com/flyingmedicords/files/Circulation+2002+%28106%29%E3%82%A2%E3%83%B3%E3%82%B3%E3%82%A6%E3%81%9D%E3%81%AE3%E3%81%A8%E3%82%8A%E3%81%BF%E3%82%93%E3%81%90Komurojpeg.jpg" style="border: none; height: 375px; width: 500px;" width="500" /></a></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"></span><br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><span style="font-size: 14pt;"> </span></span></div>
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">
</span>
<br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><span style="font-size: 14pt;"> もともと口がないはずの</span><span style="font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;">3-a</span> </span><span style="font-size: 14pt;">と</span><span style="font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;">3-b</span></span><span style="font-size: 14pt;">の左端に、それらしく削って捏っているのがお <a href="http://emoji7.jp/051ga_719874/%E3%82%AD%E3%83%A3%E3%83%A9%E3%81%AA%E3%81%A9/" style="color: #b35400;"><img alt="キャラなど のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/051ga_719874/%E3%82%AD%E3%83%A3%E3%83%A9%E3%81%AA%E3%81%A9_m.gif" style="border: none;" /></a> かりでしょうか</span><span style="font-family: 'Times New Roman', serif; font-size: 14pt;">?</span></span></div>
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">
</span>
<br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: small;"> </span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-size: small;"><span style="color: black; font-family: 'MS 明朝', serif;"> </span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">【補足的考察】</span></span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;"> </span><span style="color: red;">原図<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #006699;">2-c</span></span></span></span><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">から</span></span><span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: 14pt;"><span style="color: #009900;">3-c</span></span></span><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">を捏り、その後、口を合わせるために、</span></span><span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: #ff0099;">3-b</span></span><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">と<span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: #ff0099;">3-a</span></span></span></span></span><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">の左端を巧妙に削った</span><span style="color: red;">。。。そなの?</span></span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">【語彙】</span></span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;"> </span><span style="color: red;">「<span style="color: black;">捏る</span>」はもともと「<span style="color: black;">こねる</span>」の意味。近頃は「<span style="color: black;">ツクる</span>」「<span style="color: black;">ネツる</span>」と訓読みするのがウケる。</span></span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"></span><br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><span style="font-size: 14pt;"> </span></span></div>
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">
</span>
<br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><span style="font-size: 14pt;">訪問者:「ちっ!開いた口が。。。」</span></span></div>
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">
</span>
<br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> <span style="color: #ff0099;">さらに悪い冗談がその後のペーパーに・つ・づ・く。。。</span></span><span style="color: #009900;"> <span style="color: #ff0099; font-family: MS 明朝; font-size: xx-small;">♡</span> <a href="http://emoji7.jp/04uf5_715960/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84/" style="color: #b35400;"><sup><img alt="かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/04uf5_715960/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.gif" style="border: none;" /></sup></a></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: small;"> </span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">訪問者:「もう知らんぞ。どーなっても。<a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="You dummy! このバカちん!"><img alt="かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/050ad_708907/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.gif" style="border: none;" /></a>」</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;"><a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="click here~♡"><img alt="" border="0" height="375" src="http://blog.m3.com/flyingmedicords/files/Circulation+2002+%28106%29%E3%82%A2%E3%83%B3%E3%82%B3%E3%82%A6%E3%81%AB%E3%81%A4%E3%81%A5%E3%81%91jpeg.jpg" style="border: none; height: 375px; width: 500px;" width="500" /></a> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;">―</span><span style="color: black; font-family: 'Calligraph421 BT'; font-size: 18pt;"> Wow! It sure is jaw-dropping. </span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;">―</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> Delve a little bit further into the trick previously analyzed. When an image is cooked up into another image, the opposite is true. That is, image processing from 3-c to 2-c is possible, and vice-versa from 2-c to 3-c.</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> If there were only two images, could you guess which is which? You can’t, I bet. Though you may say what is the point of delving it, but let’s see a faked image a little bit closer. It begins to seem like an O-sign mouth of an anglerfish, isn’t it? <a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="See? でしょん?"><img alt="実写、動物、かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/04ctj_717328/%E5%AE%9F%E5%86%99%E3%80%81%E5%8B%95%E7%89%A9%E3%80%81%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.GIF" style="border: none;" /></a></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> Did you notice that each left edge of images (3-a, 3-b) without mouths were trimmed to look more real?</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span><span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: small;"><span style="color: red;"> </span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: small;"><span style="color: red;"> </span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: small;"><span style="color: red;"> <u>Supplementary Consideration</u><strong>:</strong> The original image 2-c was possibly cooked up to 3-c, and then for making mouths, each left edge of 3-b and 3-a was cut off in an artful way. Is that so?</span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: red;"> </span></span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: red;"> <u>G</u></span><span style="color: red;"><u>lossary</u><strong>:</strong> Japanese word ‘</span></span><span style="color: black; font-family: 'MS 明朝', serif;">捏る</span></span><span style="color: red;"><span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: red;">’</span><span style="color: red;">with an original meaning of ‘<span style="color: black;">Kone-ru</span>’ (v. <span style="color: black;">pug</span> in English) in kun reading, however, is more popularly pronounced ‘<span style="color: black;">Tuku-ru</span>’ or ‘<span style="color: black;">Netsu-ru</span>’ in these days.</span></span></span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;"> </span></span></div>
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;"></span></span><br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;"><span style="color: black; font-size: 14pt;">VISITOR</span></span></span></div>
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;">
</span></span>
<br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;"><span style="color: black; font-size: 14pt;"> No shit! It sure is jaw-dropping.</span></span></span></div>
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;">
</span></span>
<br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;"> </span></span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;"> To be continued for more funny jokes in later papers.<span style="font-family: MS 明朝; font-size: xx-small;">♡</span><span style="color: #009900; font-family: Verdana; font-size: x-small;"> </span><a href="http://emoji7.jp/04uf5_715960/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84/" style="color: #b35400;"><sup><img alt="かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/04uf5_715960/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.gif" style="border: none;" /></sup></a></span></span></div>
<span style="color: #ff0099; font-family: MS Pゴシック; font-size: xx-small;"> </span><span style="font-family: MS Pゴシック; font-size: xx-small;"> </span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span><br />
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;">VISITOR</span></div>
<div align="left" class="MsoNormal" style="margin: 0mm 0mm 0pt;">
<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> I don’t care anymore what happens to you!<a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="You dummy! このバカちん!"><img alt="かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/050ad_708907/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.gif" style="border: none;" /></a></span></div>
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com1tag:blogger.com,1999:blog-2127504660981560327.post-69931559519209343952013-05-07T19:08:00.003+09:002013-05-10T16:02:20.290+09:00Mitochondrial DNA that escapes from autophagy causes inflammationand heart failure.<br />
<br />
<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<a href="http://isseikomuro.blogspot.com/2013/05/nature.html"><span role="menubar">Nature.</span> 2012 May 10;485(7397):251-5. </a>doi: 10.1038/nature10992.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
<span class="highlight">Mitochondrial</span> <span class="highlight">DNA</span> that <span class="highlight">escapes</span> from <span class="highlight">autophagy</span> <span class="highlight">causes</span> <span class="highlight">inflammation</span>and <span class="highlight">heart</span> <span class="highlight">failure</span>.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.666666984558105px;">Takafumi Oka 1 (岡崇史) , Shungo Hikoso 1 </span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: 14.666666984558105px;">(彦惣俊吾)</span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: 14.666666984558105px;">, Osamu Yamaguchi 1 (山口修), Manabu Taneike 1,2(種池学), Toshihiro Takeda 1 (武田理宏) , Takahito Tamai 1 (玉井敬人), Jota Oyabu 1 (大藪丈太), Tomokazu Murakawa 1 (村川智), Hiroyuki Nakayama 3 (中山博之), Kazuhiko Nishida 1,2(西田和彦), Shizuo Akira 4,5 (審良静男), Akitsugu Yamamoto 6 (山本章嗣) , Issei Komuro 1 (</span><a href="http://komuroissei.blogspot.com/" style="font-family: arial, helvetica, clean, sans-serif; font-size: 14.666666984558105px;">小室一成</a><span style="font-family: arial, helvetica, clean, sans-serif; font-size: 14.666666984558105px;">)& Kinya Otsu 1,2 (大津 欣也)</span></div>
<div class="aff" style="background-color: white;">
<h3 class="label" style="color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.</div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/22535248">http://www.ncbi.nlm.nih.gov/pubmed/22535248</a></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://basicmed.med.ncku.edu.tw/public/project/1225-1348566873-1.pdf">http://basicmed.med.ncku.edu.tw/public/project/1225-1348566873-1.pdf</a></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.nature.com/nature/journal/v485/n7397/full/nature10992.html">http://www.nature.com/nature/journal/v485/n7397/full/nature10992.html</a><br />
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: large;"><span style="line-height: 14.770833015441895px;">Fig. 4d</span></span></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEifUrpR3vXhIYnDQBc6Yk4MhiSErEcSk59A57h0yVwNYz1e6LnMY-Lm_YsIXUqJL43TGJ18p37ByR_AA7-2mprpwwYKKt_6RKY3niogxbf5ogCdZWsSqaixeKNp3pC0vhTwnVMBW0AnCmxR/s1600/Fig1+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgZbBa_UpiqsCIptp_Rlb_O3vpyDZwlntw0gr3VRqPz4otIFc3nSzbtlmhscnu4O85N9khzuE81ipeGA-ZboBBslqesV80O9SPrIlQ7ON6Q2WO9jKq1gEZN9JmHyrhiWxgDcaYLaA-QVJ0R/s1600/Fig4D+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgZbBa_UpiqsCIptp_Rlb_O3vpyDZwlntw0gr3VRqPz4otIFc3nSzbtlmhscnu4O85N9khzuE81ipeGA-ZboBBslqesV80O9SPrIlQ7ON6Q2WO9jKq1gEZN9JmHyrhiWxgDcaYLaA-QVJ0R/s400/Fig4D+copy.jpg" width="352" /></a></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<a href="https://twitter.com/JuuichiJigen/status/218894228762279936">https://twitter.com/JuuichiJigen/status/218894228762279936</a></div>
<div>
<div class="content clearfix" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px;">
<div class="permalink-header" style="height: 48px; margin-bottom: 15px;">
<a class="account-group js-account-group js-action-profile js-user-profile-link js-nav" data-user-id="80130924" href="https://twitter.com/JuuichiJigen" style="color: #0084b4; float: left; text-decoration: none;"><img alt="論文捏造&研究不正" class="avatar js-action-profile-avatar" src="https://si0.twimg.com/profile_images/1732065634/MCB_Miyamoto_Fig4B_normal.jpg" style="border-bottom-left-radius: 5px; border-bottom-right-radius: 5px; border-top-left-radius: 5px; border-top-right-radius: 5px; border: 0px; float: left; height: 48px; margin-left: -58px; margin-top: 0px; width: 48px;" /><strong class="fullname js-action-profile-name show-popup-with-id" style="color: #333333; display: block; font-size: 18px; line-height: 1.25; margin-top: 3px; padding-top: 2px;">論文捏造&研究不正</strong><span class="username js-action-profile-name" style="color: #999999; direction: ltr; unicode-bidi: embed;"><s style="color: #bbbbbb; text-decoration: none;">@</s><b style="font-weight: normal;">JuuichiJigen</b></span></a></div>
</div>
<div class="js-tweet-text tweet-text " style="color: #333333; font-family: Georgia, 'Times New Roman', serif; font-size: 22px; line-height: 28px; white-space: pre-wrap; word-wrap: break-word;">
大阪大学大学院医学系研究科 循環器内科学 Nature誌論文 Fig.4d 最下段(CD3)の一番左の画像が、上から3段目(Ly6G)の一番右の画像と同一。 <a class="twitter-timeline-link" data-expanded-url="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10992.html" dir="ltr" href="http://t.co/up0hEfTj" rel="nofollow" style="color: #0084b4; text-decoration: none;" target="_blank" title="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10992.html"><span class="invisible" style="font-size: 0px; line-height: 0;">http://www.</span><span class="js-display-url">nature.com/nature/journal</span><span class="invisible" style="font-size: 0px; line-height: 0;">/vaop/ncurrent/full/nature10992.html</span><span class="tco-ellipsis"><span class="invisible" style="font-size: 0px; line-height: 0;"> </span>…</span></a> ケアレスミスか?念のため、他にも調査の必要性があるか?</div>
<div class="permalink-footer" style="font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px;">
<div class="js-tweet-details-fixer tweet-details-fixer">
<div class="js-tweet-stats-container tweet-stats-container ">
<ul class="stats" style="border-bottom-color: rgba(0, 0, 0, 0.0980392); border-bottom-style: solid; border-bottom-width: 1px; border-top-color: rgb(232, 232, 232); border-top-style: solid; border-top-width: 1px; list-style: none; margin: 10px 0px 0px; overflow: hidden; padding: 0px;"></ul>
</div>
<div class="client-and-actions" style="clear: both; margin-top: 10px; overflow: hidden;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2012年6月30日 - 11:30">2012年6月30日 - 11:30</span></span></div>
<div class="client-and-actions" style="clear: both; margin-top: 10px; overflow: hidden;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2012年6月30日 - 11:30"><br /></span></span></div>
<div class="client-and-actions" style="clear: both; margin-top: 10px; overflow: hidden;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2012年6月30日 - 11:30"><br /></span></span></div>
</div>
</div>
<br />
<div class="js-tweet-text tweet-text " style="color: #333333; font-family: Georgia, 'Times New Roman', serif; font-size: 22px; line-height: 28px; white-space: pre-wrap; word-wrap: break-word;">
(その後、Corrigendum が出される。指摘の件以外にも、多数の不適切な画像操作が判明)</div>
<div class="js-tweet-text tweet-text " style="color: #333333; font-family: Georgia, 'Times New Roman', serif; font-size: 22px; line-height: 28px; white-space: pre-wrap; word-wrap: break-word;">
↓ </div>
<div class="js-tweet-text tweet-text " style="color: #333333; font-family: Georgia, 'Times New Roman', serif; font-size: 22px; line-height: 28px; white-space: pre-wrap; word-wrap: break-word;">
<br /></div>
<h3 style="font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; line-height: 15.454545021057129px; margin: 0.5em 0px 0px !important;">
Erratum in</h3>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em;">
<span style="line-height: 15.4375px;"><br /></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;">Nature. 2012 Oct 11;490(7419):292.</span></span></div>
<div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;"><br /></span></span></div>
<div>
<a href="http://www.nature.com/nature/journal/v490/n7419/full/nature11515.html">http://www.nature.com/nature/journal/v490/n7419/full/nature11515.html</a></div>
</div>
<div>
<br /></div>
<div>
<div style="color: #333333; font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 23.90625px; margin-bottom: 20px; padding: 0px;">
<a href="http://dx.doi.org/10.1038/nature10992" style="color: #5c7996; text-decoration: none;"><i>Nature</i> <b>485</b>, <span class="start-page">251</span>–<span class="end-page">255</span> (<span class="year">2012</span>); doi:10.1038/nature10992</a></div>
<div style="color: #333333; font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 23.90625px; margin-bottom: 20px; padding: 0px;">
In this Letter, several images were mistakenly switched or duplicated during preparation of the artwork. In Figs 1f and 2a, the sham-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">−/−</sup> and TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup> mice panels were switched. In Fig. 4d, the panel showing CD3 staining for ODN2088 control-treated TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup> mice (now shown correctly as black-bordered panel in <a href="http://www.nature.com/nature/journal/v490/n7419/full/nature11515.html#f1" style="color: #5c7996; text-decoration: none;">Fig. 1</a> below) is a duplicate of that showing Ly6G staining for ODN2088-treated TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">−/−</sup> mice. The panel showing CD45 staining for ODN2088-treated TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup> (now shown correctly as blue-bordered panel in <a href="http://www.nature.com/nature/journal/v490/n7419/full/nature11515.html#f1" style="color: #5c7996; text-decoration: none;">Fig. 1</a> below) was prepared from the original picture of ODN2088 control-treated TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup>. In Supplementary Fig. 4c, sham-operated<i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">−/−</sup> and TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup> mice panels were switched. Finally, in Supplementary Fig. 10d, the panels showing CD3 and Ly6G staining for sham-operated <i>Tlr9<sup style="font-size: 12.222222328186035px; line-height: 0;">+/+</sup></i> mice were switched. These corrections do not alter any of the conclusions of this Letter, and the authors apologize for any confusion these errors may have caused.</div>
<div style="color: #333333; font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 23.90625px; margin-bottom: 20px; padding: 0px;">
<br /></div>
<div style="color: #333333; font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 23.90625px; margin-bottom: 20px; padding: 0px;">
</div>
<a name='more'></a><h3 style="background-image: url(http://blog.goo.ne.jp/img/template/user/1021/entry.gif); background-position: 0% 0%; background-repeat: no-repeat no-repeat; color: #00a9d9; font-size: 16px; line-height: 1.1; margin: 0px; padding: 30px 15px;">
<a href="http://blog.goo.ne.jp/lemon-stoism/e/e0f3e1732313be85a6acc20151bf11ac" style="color: #00a9d9; text-decoration: none;">大阪大学医学系グループが不適切研究!</a> (<span style="line-height: 1.1;">ブログ </span><span style="line-height: 1.1;">世界変動展望)</span></h3>
<div>
<a href="http://blog.goo.ne.jp/lemon-stoism/e/e0f3e1732313be85a6acc20151bf11ac">http://blog.goo.ne.jp/lemon-stoism/e/e0f3e1732313be85a6acc20151bf11ac</a></div>
<div>
<br /></div>
<div>
<br /></div>
</div>
<div>
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-40496403592251186842013-05-07T19:07:00.001+09:002013-05-12T22:09:02.538+09:00Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases.<a href="http://isseikomuro.blogspot.com/2013/05/j-atheroscler-thromb-2012193263-75.html" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"><span role="menubar">J Atheroscler Thromb.</span> 2012;19(3):263-75.</a><span style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"> Epub 2011 Nov 10.</span><br />
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases.</h1>
<div class="auths" style="background-color: white;">
<span style="color: #660066; font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14px;">Miyako Yuasa-Kawase (</span><span style="font-size: 14.666666984558105px;">川瀬都)</span><span style="font-size: 14px;">1), Daisaku Masuda (</span><span style="font-size: 14.666666984558105px;">増田大作)</span><span style="font-size: 14px;">1), Taiji Yamashita 1), Ryota Kawase 1), Hajime Nakaoka 1), Miwako Inagaki (</span><span style="font-size: 14.666666984558105px;">稲垣美和子)</span><span style="font-size: 14px;">1), Kazuhiro Nakatani (</span><span style="font-size: 14.666666984558105px;">中谷和弘) </span><span style="font-size: 14px;">1), Kazumi Tsubakio-Yamamoto (</span><span style="font-size: 14.666666984558105px;">山本和美)</span><span style="font-size: 14px;">1), Tohru Ohama 1) 3), Akifumi Matsuyama 2), Makoto Nishida (</span><span style="font-size: 14.666666984558105px;">西田誠) </span><span style="font-size: 14px;">1) 3), Masato Ishigami (</span><span style="font-size: 14.666666984558105px;">石神眞人)</span><span style="font-size: 14px;">4), Toshiharu Kawamoto 5), Issei Komuro </span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: 14.666666984558105px;">(</span><a href="http://komuroissei.blogspot.com/" style="font-family: arial, helvetica, clean, sans-serif; font-size: 14.666666984558105px;">小室一成</a><span style="font-family: arial, helvetica, clean, sans-serif; font-size: 14.666666984558105px;">)</span><span style="color: #660066; font-family: arial, helvetica, clean, sans-serif; font-size: 14px;"> 1), Shizuya Yamashita (</span><span style="color: #660066; font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.666666984558105px;">山下静也)</span></span><span style="color: #660066; font-family: arial, helvetica, clean, sans-serif; font-size: 14px;"> 1)</span></div>
<div class="aff" style="background-color: white;">
<h3 class="label" style="color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14px; line-height: 14.78125px;">1) Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine. 2) Department of Somatic Stem Cell Therapy, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation. 3) Health Care Center, Osaka University. 4) Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine. 5) Kure Heart Center, National Hospital Organization Kure Medical Center.</span></span></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/22075538">http://www.ncbi.nlm.nih.gov/pubmed/22075538</a></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="https://www.jstage.jst.go.jp/article/jat/19/3/19_10603/_article">https://www.jstage.jst.go.jp/article/jat/19/3/19_10603/_article</a></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<div style="text-align: center;">
<b>Funding</b></div>
This work was supported by the following grants: a grant-in-aid for Scientific Research (No. 18659267) to S. Yamashita from the Minist of Education, Science, Sports and Culture in Japan; a grant from Mitsui Life Social Welfare Foundation to S. Yamashita; a Takeda Medical Researech Foundation Grant to S. Yamashita; and in part by the Program for the Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO) to A. Matsuyama and S. Yamashita.<br />
<br />
<br />
<hr />
<div class="content clearfix" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px;">
</div>
<div class="content clearfix" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px;">
</div>
<br />
<br />
</div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
Fig.2 (A is the same as C)</div>
<div class="separator" style="clear: both; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjkbYUvVzNDr11oh1YmfgOaB1tpagNM9DM_ScviWi6PdWMsney4aotq6hT54XgxNteu9XLrrdrCnh6oiSWzL3IXxuhBAvBvoEPXhHMY0_0n_sYfjQoyJJFyWp4HoLlYkNbYId9R1_jliB3v/s1600/Fig2+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="287" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjkbYUvVzNDr11oh1YmfgOaB1tpagNM9DM_ScviWi6PdWMsney4aotq6hT54XgxNteu9XLrrdrCnh6oiSWzL3IXxuhBAvBvoEPXhHMY0_0n_sYfjQoyJJFyWp4HoLlYkNbYId9R1_jliB3v/s400/Fig2+copy.jpg" width="400" /></a></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<br />
<br />
<hr />
<div class="content clearfix" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px;">
</div>
<div class="content clearfix" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px;">
<div class="permalink-header" style="height: 48px; margin-bottom: 15px;">
<a href="https://twitter.com/JuuichiJigen/status/324561004094697472" style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;"><br />https://twitter.com/JuuichiJigen/status/324561004094697472</a></div>
</div>
</div>
<div class="content clearfix" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px;">
<div class="permalink-header" style="height: 48px; margin-bottom: 15px;">
<a class="account-group js-account-group js-action-profile js-user-profile-link js-nav" data-user-id="80130924" href="https://twitter.com/JuuichiJigen" style="color: #0084b4; float: left; text-decoration: none;"><img alt="論文捏造&研究不正" class="avatar js-action-profile-avatar" src="https://si0.twimg.com/profile_images/1732065634/MCB_Miyamoto_Fig4B_normal.jpg" style="border-bottom-left-radius: 5px; border-bottom-right-radius: 5px; border-top-left-radius: 5px; border-top-right-radius: 5px; border: 0px; float: left; height: 48px; margin-left: -58px; margin-top: 0px; width: 48px;" /><strong class="fullname js-action-profile-name show-popup-with-id" style="color: #333333; display: block; font-size: 18px; line-height: 1.25; margin-top: 3px; padding-top: 2px;">論文捏造&研究不正</strong><span class="username js-action-profile-name" style="color: #999999; direction: ltr; unicode-bidi: embed;"><s style="color: #bbbbbb; text-decoration: none;">@</s><b style="font-weight: normal;">JuuichiJigen</b></span></a></div>
</div>
<div class="js-tweet-text tweet-text " style="color: #333333; font-family: Georgia, 'Times New Roman', serif; font-size: 22px; line-height: 28px; white-space: pre-wrap; word-wrap: break-word;">
今話題の阪大循環器内科グループの論文:J Atheroscler Thromb. 2012;19(3):263-75. Fig.2A (RCA) と Fig.2C (RCIA) の写真が同一。<a class="twitter-timeline-link" data-expanded-url="https://www.jstage.jst.go.jp/article/jat/19/3/19_10603/_pdf" dir="ltr" href="https://t.co/fQvw0kIWar" rel="nofollow" style="color: #0084b4; text-decoration: none;" target="_blank" title="https://www.jstage.jst.go.jp/article/jat/19/3/19_10603/_pdf"><span class="invisible" style="color: #0084b4; font-size: 0px; line-height: 0;">https://www.</span><span class="js-display-url" style="color: #0084b4;">jstage.jst.go.jp/article/jat/19</span><span class="invisible" style="color: #0084b4; font-size: 0px; line-height: 0;">/3/19_10603/_pdf</span><span class="tco-ellipsis" style="color: #0084b4;"><span class="invisible" style="font-size: 0px; line-height: 0;"> </span>…</span></a></div>
<div class="permalink-footer" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px;">
<div class="js-tweet-details-fixer tweet-details-fixer">
<div class="client-and-actions" style="clear: both; margin-top: 10px; overflow: hidden;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年4月18日 - 1:32">2013年4月18日 - 1:32</span></span></div>
<div class="client-and-actions" style="clear: both; margin-top: 10px; overflow: hidden;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年4月18日 - 1:32"></span></span><br />
<br />
<div style="color: black; font-family: arial, helvetica, clean, sans-serif; font-size: 13.63636302947998px; line-height: 14.772727012634277px; margin-bottom: 0.5em; margin-top: 0.5em;">
<hr />
<div class="content clearfix" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px;">
<div class="permalink-header" style="height: 48px; margin-bottom: 15px;">
</div>
</div>
</div>
<div style="color: black; font-family: arial, helvetica, clean, sans-serif; font-size: 13.63636302947998px; line-height: 14.772727012634277px; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<br />
<div class="stream-item-header" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年4月18日 - 1:32"><a class="account-group js-account-group js-action-profile js-user-profile-link js-nav" data-user-id="118041552" href="https://twitter.com/druoh" style="color: #999999; text-decoration: none;"><img alt="UO" class="avatar js-action-profile-avatar" src="https://si0.twimg.com/profile_images/3525807181/3ebe5557721cac8e16096c6cf599d4aa_normal.jpeg" style="border-bottom-left-radius: 5px; border-bottom-right-radius: 5px; border-top-left-radius: 5px; border-top-right-radius: 5px; border: 0px; float: left; height: 48px; margin-left: -58px; margin-top: 3px; width: 48px;" /><strong class="fullname js-action-profile-name show-popup-with-id" style="color: #0084b4; text-decoration: underline;">UO</strong> <span class="username js-action-profile-name" style="direction: ltr; unicode-bidi: embed;"><s style="color: #bbbbbb; text-decoration: none;">@</s><b style="font-weight: normal;">druoh</b></span></a><small class="time" style="color: #bbbbbb; float: right; font-size: 12px; margin-right: 5px; margin-top: 1px; position: relative;"><a class="tweet-timestamp js-permalink js-nav" href="https://twitter.com/druoh/status/324579214273703936" style="color: #999999; text-decoration: none;" title="2013年4月18日 - 2:44"><span class="_timestamp js-short-timestamp " data-long-form="true" data-time="1366220689">4月18日</span></a></small></span></span></div>
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年4月18日 - 1:32"></span></span><br />
<div class="js-tweet-text" style="font-size: 14.44444465637207px; line-height: 17.98611068725586px; white-space: pre-wrap; word-wrap: break-word;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年4月18日 - 1:32">2Cはcommon iliacじゃないなwwてか、coronaryの写真で腹部以下の話をされてもw誰だよ、これ見逃したの。</span></span></div>
<div class="expanded-content js-tweet-details-dropdown" style="font-size: 14.44444465637207px; height: auto; line-height: 17.98611068725586px; overflow: hidden; position: relative;">
<div class="js-tweet-details-fixer tweet-details-fixer">
<div class="client-and-actions" style="clear: both; margin-top: 10px; overflow: hidden;">
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年4月18日 - 1:32"><span class="metadata" style="color: #999999; overflow: hidden;"><span title="2013年4月18日 - 2:44">2013年4月18日 - 2:44</span> · <a class="permalink-link js-permalink js-nav" href="https://twitter.com/druoh/status/324579214273703936" style="color: #999999; text-decoration: none;">詳細</a></span></span></span><br />
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年4月18日 - 1:32"><br /></span></span>
<span class="metadata" style="color: #999999; font-size: 12px; line-height: 24px; overflow: hidden;"><span title="2013年4月18日 - 1:32"><br /></span></span></div>
</div>
</div>
</div>
</div>
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-69703591892677738832013-05-07T19:05:00.001+09:002014-05-02T12:16:39.208+09:00A crucial role for adipose tissue p53 in the regulation of insulin resistance.<a href="http://isseikomuro.blogspot.com/2013/05/nat-med-2009-sep1591082-7.html" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"><span role="menubar">Nat Med.</span> 2009 Sep;15(9):1082-7.</a><span style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"> doi: 10.1038/nm.2014. Epub 2009 Aug 30.</span><br />
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
A crucial role for adipose tissue p53 in the regulation of insulin resistance.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15px;">Tohru Minamino 1,2,7, Masayuki Orimo 1,7, Ippei Shimizu 1,7, Takeshige Kunieda 1, Masataka Yokoyama 1, Takashi Ito 1, Aika Nojima 1, Akira Nabetani 3, Yuichi Oike 2,4, Hisahiro Matsubara 5, Fuyuki Ishikawa 3 & Issei Komuro 1,6</span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;"> Medicine, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.</span></div>
<div class="aff">
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<ol class="decimal" style="clear: both; font-family: Verdana, arial, Helvetica, sans-serif; font-size: 12px; line-height: normal;">
<li id="a1">Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.</li>
<li id="a2">PRESTO, Japan Science and Technology Agency, Saitama, Japan.</li>
<li id="a3">Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Kyoto, Japan.</li>
<li id="a4">Department of Molecular Genetics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.</li>
<li id="a5">Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.</li>
<li id="a6">Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.</li>
<li id="a7">These authors contributed equally to this work.</li>
</ol>
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/19718037">http://www.ncbi.nlm.nih.gov/pubmed/19718037</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.nature.com/nm/journal/v15/n9/full/nm.2014.html">http://www.nature.com/nm/journal/v15/n9/full/nm.2014.html</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.nature.com/nm/journal/v15/n9/pdf/nm.2014.pdf">http://www.nature.com/nm/journal/v15/n9/pdf/nm.2014.pdf</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<span style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.375px;">This work was supported by a </span></span><span style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.375px;">Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports </span><span style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.375px;">and Culture and Health and Labor Sciences Research Grants (to I.K.); a Grant-in-</span><br />
<span style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.375px;">Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science </span></span><span style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.375px;">and Technology of Japan; and grants from the Suzuken Memorial Foundation, </span><span style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.375px;">the Japan Diabetes Foundation, the Ichiro Kanehara Foundation, the Tokyo </span><span style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.375px;">Biochemical Research Foundation, the Takeda Science Foundation, the Cell Science </span><span style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.375px;">Research Foundation and the Japan Foundation of Applied Enzymology (to T.M.).</span></div>
<hr style="background-color: white; color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 11.111111640930176px; line-height: 14.392361640930176px;" />
<div style="line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="background-color: #f3f3f3;"><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;">Supplemental Fig. 2c </span><span style="line-height: 21.33333396911621px;">の</span><span style="line-height: 18px;">WT (HF/HS) </span><span lang="JA" style="line-height: 18px;">の</span><span style="line-height: 18px;">CT scan</span><span lang="JA" style="line-height: 18px;">と、</span></span></b></span></div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="background-color: #f3f3f3;"><b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="line-height: 18px;">Supplemental Fig. 2c </span><span style="line-height: 21.33333396911621px;">の</span><span style="line-height: 18px;">G4 (HF/HS)</span></span></b></span><b style="line-height: 1.0915em;"><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="line-height: 17.33333396911621px;">の</span><span style="line-height: 17.33333396911621px;">CT scan</span></span></b><b style="line-height: 1.0915em;"><span style="font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 21.33333396911621px;">と、</span></span></b></div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="background-color: #f3f3f3;"><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;">Supplemental Fig. 2d </span><span style="line-height: 21.33333396911621px;">の</span><span style="line-height: 18px;">Pre operation</span><span lang="JA" style="line-height: 18px;">の</span><span style="line-height: 18px;">CT scan</span><span lang="JA" style="line-height: 18px;">が同じ個体?</span><span class="apple-converted-space" style="line-height: 1.0915em;"><span style="line-height: 18px;"> </span></span></span></b></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div class="separator" style="background-color: white; clear: both; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; text-align: center;">
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div class="separator" style="clear: both; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj80Kogx69QLnWO3qJWUV-x80uRU-o1SKzldQ9NKZJUhukO91uZ4Y5ICGMt_mI2f383p-hAfQ5w4ZxMZfc0MG58fx8Ydf01cx4gW8s32rbI7lJ9UHULFcpwfRJKHRj68EC3wpAQIo22wvp0/s1600/Nature+Med+2009+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj80Kogx69QLnWO3qJWUV-x80uRU-o1SKzldQ9NKZJUhukO91uZ4Y5ICGMt_mI2f383p-hAfQ5w4ZxMZfc0MG58fx8Ydf01cx4gW8s32rbI7lJ9UHULFcpwfRJKHRj68EC3wpAQIo22wvp0/s640/Nature+Med+2009+copy.jpg" height="406" width="640" /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<hr style="background-color: white; color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 11.111111640930176px; line-height: 14.392361640930176px;" />
<div style="line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="line-height: 1.0915em;">
<span style="background-color: white; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial;">Supplemental Fig. 2c</span></span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">の一番右、</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">Lean tissue/BW</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">の棒グラフの</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">G4 (HS/HS)</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">と</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">G4 Trp53+/- (HS/HS)</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">は、</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">mean</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">と</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">SEM</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">が完全に一致。遺伝型が違うのに</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">n=5</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">で</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">mean</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">と</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">SEM</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">が完全一致するのは極めて稀</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">?CT scan</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 20px;">のこれだけ似た画像を元に作ればあり得る</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;">?<span class="apple-converted-space"> </span></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
</div>
<div class="aff" style="line-height: 1.0915em;">
<span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><span class="apple-converted-space"><br /></span></span></div>
<hr style="background-color: white; color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 11.111111640930176px; line-height: 14.392361640930176px;" />
<span style="color: red; font-size: large;"><b>この不適切に流用された画像は、その後、Natureグループにより、何の訂正告知もなしにこっそりOn line上で差し替えたられました。読書を騙す行為であり、前例のない悪質な行為です。</b></span><br />
<hr style="background-color: white; color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 11.111111640930176px; line-height: 14.392361640930176px;" />
<br />
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<br />
<div style="-webkit-text-stroke-width: 0px; color: black; font-family: 'MS PGothic'; font-size: medium; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 1.0915em; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px;">
<div style="margin: 0px;">
<br /></div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-3146109451720941412013-05-07T19:04:00.002+09:002013-05-28T01:52:19.617+09:00IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.<a href="http://www.blogger.com/Nature.%202008%20Jul%2017;454(7202):345-9." style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"><span role="menubar">Nature.</span> 2008 Jul 17;454(7202):345-9. </a><span style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">doi: 10.1038/nature07027. Epub 2008 Jun 4.</span><br />
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15px;">Weidong Zhu 1,8, Ichiro Shiojima 1,8, Yuzuru Ito 2,8, Zhi Li 1, Hiroyuki Ikeda 1, Masashi Yoshida 1, Atsuhiko T. Naito 1, Jun-ichiro Nishi1, Hiroo Ueno 3, Akihiro Umezawa 4, Tohru Minamino 1, Toshio Nagai 1, Akira Kikuchi 5, Makoto Asashima 2,6,7 & Issei Komuro 1</span></span></div>
<div class="aff">
<h3 class="label" style="background-color: white; color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<br />
<br />
<br />
<br />
<br />
<li id="a1" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;">Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan</li>
<li id="a2" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;">ICORP Organ Regeneration Project, Japan Science and Technology Agency (JST), Tokyo 153-8902, Japan</li>
<li id="a3" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;">Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA</li>
<li id="a4" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;">Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo 157-8535, Japan</li>
<li id="a5" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;">Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan</li>
<li id="a6" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;">Department of Life Sciences (Biology), Graduate School of Arts and Science, The University of Tokyo, Tokyo 153-8902, Japan</li>
<li id="a7" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;">National Institute of Advanced Industrial Sciences and Technology (AIST), Ibaraki 305-8562, Japan</li>
<li id="a8" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;">These authors contributed equally to this work.</li>
<li id="a8" style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 10px; line-height: normal;"><br /></li>
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/18528331">http://www.ncbi.nlm.nih.gov/pubmed/18528331</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.nature.com/nature/journal/v454/n7202/full/nature07027.html">http://www.nature.com/nature/journal/v454/n7202/full/nature07027.html</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.nature.com/nature/journal/v454/n7202/pdf/nature07027.pdf">http://www.nature.com/nature/journal/v454/n7202/pdf/nature07027.pdf</a></div>
<div style="background-color: white; margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="text-align: center;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 17.45833396911621px;"><b>ACKNOWLEDGMENTS</b></span></span></div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">This work was supported by a </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">and Culture and Health and Labor Sciences Research Grants (to I.K.); a Grant-in-</span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science </span><br />
<div style="display: inline !important;">
<div style="display: inline !important;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">and Technology of Japan; and grants from the Suzuken Memorial Foundation, </span></div>
</div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"></span><br />
<div style="display: inline !important;">
<div style="display: inline !important;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">the Japan Diabetes Foundation, the Ichiro Kanehara Foundation, the Tokyo </span></div>
</div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">
</span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"></span>
<br />
<div style="display: inline !important;">
<div style="display: inline !important;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">Biochemical Research Foundation, the Takeda Science Foundation, the Cell Science </span></div>
</div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">
</span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"></span>
<div style="display: inline !important;">
<div style="display: inline !important;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">Research Foundation and the Japan Foundation of Applied Enzymology (to T.M.).</span></div>
</div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;">
</span><br />
<br />
<br />
<br />
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<hr style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
</div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Arial, Helvetica, sans-serif;"><b style="background-color: #f3f3f3;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 1c: beta-Actin </span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">左から</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">1, 2</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">列目が類似</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">?<span class="apple-converted-space"> </span></span></b></span><span style="background-color: white; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhRDqpeOwSj1vF0-qvTEsI27McEZ4qAxR5DdbIOjZLoi24mH5VttieXQtW-suRsSoS7mvy9XKMHnbhzvoXOA53lJnlo81cTdZHOoFwIV8sLQ3shxXYBxLsMmXd0uYni8dqw2du6mxSkBrJn/s1600/Fig1+copy.jpg" imageanchor="1" style="clear: left; display: inline !important; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 1em; margin-right: 1em; text-align: center;"><img border="0" height="300" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhRDqpeOwSj1vF0-qvTEsI27McEZ4qAxR5DdbIOjZLoi24mH5VttieXQtW-suRsSoS7mvy9XKMHnbhzvoXOA53lJnlo81cTdZHOoFwIV8sLQ3shxXYBxLsMmXd0uYni8dqw2du6mxSkBrJn/s400/Fig1+copy.jpg" width="400" /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div class="separator" style="background-color: white; clear: both; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhRDqpeOwSj1vF0-qvTEsI27McEZ4qAxR5DdbIOjZLoi24mH5VttieXQtW-suRsSoS7mvy9XKMHnbhzvoXOA53lJnlo81cTdZHOoFwIV8sLQ3shxXYBxLsMmXd0uYni8dqw2du6mxSkBrJn/s1600/Fig1+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhRDqpeOwSj1vF0-qvTEsI27McEZ4qAxR5DdbIOjZLoi24mH5VttieXQtW-suRsSoS7mvy9XKMHnbhzvoXOA53lJnlo81cTdZHOoFwIV8sLQ3shxXYBxLsMmXd0uYni8dqw2du6mxSkBrJn/s1600/Fig1+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<hr style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="line-height: 1.0915em;">
<span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span><b><span style="background-color: #f3f3f3; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;">Fig. 3b: beta-Actin </span><span lang="JA" style="line-height: 18px;">左から</span><span style="line-height: 18px;">1, 2</span><span lang="JA" style="line-height: 18px;">列目が類似</span><span style="line-height: 18px;">?<span class="apple-converted-space"> </span></span></span></b><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNDV8Yalkf_hwxYosab4OZd2mpSNeEbYl7dKJlKpDXMAUIfIYu_NSYI50b2ZuW5IPyp8kk_ZMBPX0kShy1IgPIHq0SUBeXMwew3G_0Oubwzb5_ltWKprgfzdoUTGcyTmEFf0cpAYqsUmue/s1600/Fig3b+copy.jpg" imageanchor="1" style="clear: left; display: inline !important; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 1em; margin-right: 1em; text-align: center;"><img border="0" height="276" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNDV8Yalkf_hwxYosab4OZd2mpSNeEbYl7dKJlKpDXMAUIfIYu_NSYI50b2ZuW5IPyp8kk_ZMBPX0kShy1IgPIHq0SUBeXMwew3G_0Oubwzb5_ltWKprgfzdoUTGcyTmEFf0cpAYqsUmue/s400/Fig3b+copy.jpg" width="400" /></a></div>
<div class="separator" style="background-color: white; clear: both; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNDV8Yalkf_hwxYosab4OZd2mpSNeEbYl7dKJlKpDXMAUIfIYu_NSYI50b2ZuW5IPyp8kk_ZMBPX0kShy1IgPIHq0SUBeXMwew3G_0Oubwzb5_ltWKprgfzdoUTGcyTmEFf0cpAYqsUmue/s1600/Fig3b+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNDV8Yalkf_hwxYosab4OZd2mpSNeEbYl7dKJlKpDXMAUIfIYu_NSYI50b2ZuW5IPyp8kk_ZMBPX0kShy1IgPIHq0SUBeXMwew3G_0Oubwzb5_ltWKprgfzdoUTGcyTmEFf0cpAYqsUmue/s1600/Fig3b+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhNDV8Yalkf_hwxYosab4OZd2mpSNeEbYl7dKJlKpDXMAUIfIYu_NSYI50b2ZuW5IPyp8kk_ZMBPX0kShy1IgPIHq0SUBeXMwew3G_0Oubwzb5_ltWKprgfzdoUTGcyTmEFf0cpAYqsUmue/s1600/Fig3b+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<hr style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="line-height: 1.0915em;">
<b style="background-color: #eeeeee;"><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 3e: alpha-MHC 3</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">、</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">5</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">列目、バンドの消去?</span><span class="apple-converted-space"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span><span style="line-height: 18px;"><br /><span style="background-position: initial initial; background-repeat: initial initial;">Fig. 3e: alpha-MHC </span></span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">左から</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">1, 4, 6</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">列目および</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">GATA-4 </span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">左から</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">5</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">列目が類似</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">?<span class="apple-converted-space"> </span></span></span></b></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span></div>
<div class="separator" style="background-color: white; clear: both; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjqfPTu-S5VQ29-UAUkYD-ScgXPxDMCDYUw-Ms1lq9SdBIuOzxZwiBsOhpOHpg8qZIFqpYhmaWdKJWTIz6IHWtUP6YitwhwJi67zH1R9O049PhVOSIsHvKLfo6FGLHI4m1MTHedt9RwqYk6/s1600/Fig3e+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="293" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjqfPTu-S5VQ29-UAUkYD-ScgXPxDMCDYUw-Ms1lq9SdBIuOzxZwiBsOhpOHpg8qZIFqpYhmaWdKJWTIz6IHWtUP6YitwhwJi67zH1R9O049PhVOSIsHvKLfo6FGLHI4m1MTHedt9RwqYk6/s400/Fig3e+copy.jpg" width="400" /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<hr style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="line-height: 1.0915em;">
<span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span><span style="background-color: #f3f3f3; font-family: Arial, Helvetica, sans-serif;"><b><span style="line-height: 18px;">Fig. 3e: GATA-4 </span><span lang="JA" style="line-height: 18px;">左から</span><span style="line-height: 18px;">1, 6</span><span lang="JA" style="line-height: 18px;">列目が類似</span><span style="line-height: 18px;">?<span class="apple-converted-space"> </span></span></b></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div class="separator" style="background-color: white; clear: both; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgCY-e4x0yA9vNP5669I53OkRcAv8GtjUhyIYauLAzMUWmNhC4yOLm5Nu47TXL5ht49UzS0RMca68drQbhFtToP-FJCIavRzDxbZqVL3M1t7UKjOxQvcC9pOGSWoyxbHSkdTxeIInC0J5qr/s1600/Fig3e+2+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="292" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgCY-e4x0yA9vNP5669I53OkRcAv8GtjUhyIYauLAzMUWmNhC4yOLm5Nu47TXL5ht49UzS0RMca68drQbhFtToP-FJCIavRzDxbZqVL3M1t7UKjOxQvcC9pOGSWoyxbHSkdTxeIInC0J5qr/s400/Fig3e+2+copy.jpg" width="400" /></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgCY-e4x0yA9vNP5669I53OkRcAv8GtjUhyIYauLAzMUWmNhC4yOLm5Nu47TXL5ht49UzS0RMca68drQbhFtToP-FJCIavRzDxbZqVL3M1t7UKjOxQvcC9pOGSWoyxbHSkdTxeIInC0J5qr/s1600/Fig3e+2+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgCY-e4x0yA9vNP5669I53OkRcAv8GtjUhyIYauLAzMUWmNhC4yOLm5Nu47TXL5ht49UzS0RMca68drQbhFtToP-FJCIavRzDxbZqVL3M1t7UKjOxQvcC9pOGSWoyxbHSkdTxeIInC0J5qr/s1600/Fig3e+2+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgCY-e4x0yA9vNP5669I53OkRcAv8GtjUhyIYauLAzMUWmNhC4yOLm5Nu47TXL5ht49UzS0RMca68drQbhFtToP-FJCIavRzDxbZqVL3M1t7UKjOxQvcC9pOGSWoyxbHSkdTxeIInC0J5qr/s1600/Fig3e+2+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span><span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span><br />
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span>
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<hr style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="line-height: 1.0915em;">
<span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span><span style="background-color: #f3f3f3;"><b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 3e</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">の</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Nkx2.5</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">左</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">1</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">から</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">4</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">列目をやや拡大して垂直に反転すると</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">GATA-4 </span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">左</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">1</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">から</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">4</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">列目とよく似ている</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">?<span class="apple-converted-space"> </span></span></span></b></span><span style="background-color: white; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiehsDG9M6ca3wNwKdNQFyGEldCrlf79qAAeg7t7_WqSxiraJznkGuBcVMStEHoMhnqUpjN4weyp96tg1T-_F2u-8dpWLGG393Hgl7CKCRCkgWAR-4WWmgdBFwGAgYeLcXDfSPXisx2fA9t/s1600/Fig3e.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiehsDG9M6ca3wNwKdNQFyGEldCrlf79qAAeg7t7_WqSxiraJznkGuBcVMStEHoMhnqUpjN4weyp96tg1T-_F2u-8dpWLGG393Hgl7CKCRCkgWAR-4WWmgdBFwGAgYeLcXDfSPXisx2fA9t/s400/Fig3e.jpg" width="312" /></a></div>
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br /></span></div>
<hr style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="line-height: 1.0915em;">
<span style="background-color: #f3f3f3; font-family: Arial, Helvetica, sans-serif;"><b><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Supplementary Figure S3 e<span class="apple-converted-space"> </span></span><span style="line-height: 18px;"><br /><span style="background-position: initial initial; background-repeat: initial initial;">Nkx2.5 (-) </span></span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">と</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">GATA4 BP4-2</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">のバンドが類似?</span><span class="apple-converted-space"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span></b></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgQppImx5zWtEEYWXq2mxq8o-IHGmnNdpl35o01f6pyTZFf3KSB4dybtDShwgZ_GlSsZwQFSrYtp6_4hL2yCoOcYspgwz34pX2duM3Z_qJoL_KRaPHdchbiMwt0Vbi1bbes3IOc5EyHz5Tu/s1600/Sup+FigS3e.jpg" imageanchor="1" style="clear: left; display: inline !important; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 1em; margin-right: 1em; text-align: center;"><img border="0" height="296" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgQppImx5zWtEEYWXq2mxq8o-IHGmnNdpl35o01f6pyTZFf3KSB4dybtDShwgZ_GlSsZwQFSrYtp6_4hL2yCoOcYspgwz34pX2duM3Z_qJoL_KRaPHdchbiMwt0Vbi1bbes3IOc5EyHz5Tu/s400/Sup+FigS3e.jpg" width="400" /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<hr style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="line-height: 1.0915em;">
<span style="background-color: #f3f3f3; font-family: Arial, Helvetica, sans-serif;"><b><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Supplementary Figure S3 f<span class="apple-converted-space"> </span></span><span style="line-height: 18px;"><br /><span style="background-position: initial initial; background-repeat: initial initial;">Nkx2.5 (-) </span></span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">と</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> beta-actin (-) </span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">のバンドが類似(縮尺変更か?)</span><span class="apple-converted-space"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span></b></span></div>
<div class="separator" style="background-color: white; clear: both; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgQppImx5zWtEEYWXq2mxq8o-IHGmnNdpl35o01f6pyTZFf3KSB4dybtDShwgZ_GlSsZwQFSrYtp6_4hL2yCoOcYspgwz34pX2duM3Z_qJoL_KRaPHdchbiMwt0Vbi1bbes3IOc5EyHz5Tu/s1600/Sup+FigS3e.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgQppImx5zWtEEYWXq2mxq8o-IHGmnNdpl35o01f6pyTZFf3KSB4dybtDShwgZ_GlSsZwQFSrYtp6_4hL2yCoOcYspgwz34pX2duM3Z_qJoL_KRaPHdchbiMwt0Vbi1bbes3IOc5EyHz5Tu/s1600/Sup+FigS3e.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><br /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhWxgPFg3yMX1lX5Fe-lPRhOs2-yJs-iGEb6WpGriO7pHPGKr2bivAp7Z0t0nl526AjNG_5KljLSfH8RLVNPVcChCPNFm-TYc8HgMXEZg7ztET_jWmDDCULUDjkoQth91fx9lAQbOdL8IgE/s1600/Sup+FigS3f.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhWxgPFg3yMX1lX5Fe-lPRhOs2-yJs-iGEb6WpGriO7pHPGKr2bivAp7Z0t0nl526AjNG_5KljLSfH8RLVNPVcChCPNFm-TYc8HgMXEZg7ztET_jWmDDCULUDjkoQth91fx9lAQbOdL8IgE/s400/Sup+FigS3f.jpg" width="312" /></a></div>
<br />
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<br />
<hr />
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-1974444711305572232013-05-07T19:03:00.001+09:002013-05-11T18:59:26.971+09:00Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes.<br />
<br />
<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<a href="http://isseikomuro.blogspot.com/2013/05/j-biol-chem.html"><span role="menubar">J Biol Chem.</span> 2004 Mar 19;279(12):11384-91.</a> Epub 2003 Dec 31.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15px;">Katsuhisa Matsuura ‡§, Toshio Nagai ‡, Nobuhiro Nishigaki ‡¶, Tomomi Oyama ‡, Junichiro Nishi ‡, Hiroshi Wada ‡, Masanori Sano ‡, Haruhiro Tok o‡, Hiroshi Akazawa ‡, Toshiaki Sato ∥, Haruaki Nakaya ∥, Hiroshi Kasanuki § and Issei Komuro ‡,**</span></span></div>
<div class="aff" style="background-color: white;">
<h3 class="label" style="color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<ol class="affiliation-list showaffil" style="border: 0px; list-style: none; margin: 1em 24px 1em 25.875px; outline-style: none; padding: 0px; vertical-align: baseline;">
<li class="aff" style="border: 0px; margin: 0px; outline-style: none; padding: 0px; vertical-align: baseline;"><span style="color: #403838; font-family: Lucida Sans Unicode, Arial, Lucida Grande, Tahoma, Verdana, Helvetica, sans-serif;"><span style="font-size: 17px; line-height: 0px;">‡Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan, the §Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo 162-0054, Japan, the ¶Takeda Chemical Industries, LTD, Osaka 540-8645, Japan, and the ∥Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan </span></span></li>
<li class="aff" style="border: 0px; margin: 0px; outline-style: none; padding: 0px; vertical-align: baseline;"><span style="color: #403838; font-family: Lucida Sans Unicode, Arial, Lucida Grande, Tahoma, Verdana, Helvetica, sans-serif;"><span style="font-size: 17px; line-height: 0px;"><br /></span></span></li>
<li class="aff" style="border: 0px; margin: 0px; outline-style: none; padding: 0px; vertical-align: baseline;"><span style="color: #403838; font-family: Lucida Sans Unicode, Arial, Lucida Grande, Tahoma, Verdana, Helvetica, sans-serif;"><span style="font-size: 17px; line-height: 0px;">** To whom correspondence should be addressed: Dept. of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670 Japan. Tel.: 81-43-226-2097; Fax: 81-43-226-2096; E-mail:komuro-tky@umin.ac.jp.</span></span></li>
</ol>
</div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/14702342">http://www.ncbi.nlm.nih.gov/pubmed/14702342</a></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.jbc.org/content/279/12/11384.long">http://www.jbc.org/content/279/12/11384.long</a></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<div style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<br />
<div style="font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<hr style="font-size: 0.8465em; line-height: 1.0915em;" />
<div style="font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.600000381469727px; line-height: 14.399999618530273px; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
<div style="font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
<div style="color: #666666; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13px; line-height: 18px; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<div style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="background-color: #efefef; color: black; line-height: 18px;"><b><span style="font-family: Arial, Helvetica, sans-serif;">Fig3</span></b></span></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #efefef; color: black; line-height: 18px;"></span><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;">右の</span><span style="background-color: #efefef; color: black; line-height: 18px;">MLC-2v</span><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;">と</span><span style="background-color: #efefef; color: black; line-height: 18px;">cardiac alpha-actin</span><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;">が類似</span></span></b></div>
<div class="separator" style="clear: both; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjoaO5kTp-a3Qs12UkvCGUqPdobmi_AqhJpqUuUtdTBtSTDC9ErE6qynEGpIhbh_cimgL5t40eaYuZCjECbmpV_DYp3_om0frhohtZw5RcrwL1P8SCXDsWMaY3OaZXnnholEuqODD14vd4Y/s1600/Fig3+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="301" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjoaO5kTp-a3Qs12UkvCGUqPdobmi_AqhJpqUuUtdTBtSTDC9ErE6qynEGpIhbh_cimgL5t40eaYuZCjECbmpV_DYp3_om0frhohtZw5RcrwL1P8SCXDsWMaY3OaZXnnholEuqODD14vd4Y/s400/Fig3+copy.jpg" width="400" /></a></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; color: black; line-height: 18px;"><br /></span></span></b></div>
<div style="color: #666666; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<br />
<div style="font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<hr style="font-size: 0.8465em; line-height: 1.0915em;" />
<br /></div>
* This study was supported by a grant-in-aid for Scientific Research, Developmental Scientific Research, and Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, and Culture, Takeda Medical Research Foundation, Uehara Memorial Foundation, grant-in-aid of The Japan Medical Association, The Kato Memorial Trust for Nambyo Research, Takeda Science Foundation, and a Japan Heart Foundation Research Grant. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
</div>
</div>
</div>11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-64377459195835667232013-05-07T19:01:00.001+09:002014-04-22T22:37:45.917+09:00Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1.<br />
<br />
<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<a href="http://isseikomuro.blogspot.com/2013/05/biochem-biophys-res-commun-2004-sep.html"><span role="menubar">Biochem Biophys Res Commun.</span> 2004 Sep 10;322(1):310-9.</a></div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14px;">Doubun Hayashi a, b, Sumiyo Kudoh a, Ichiro Shiojima a, Yunzeng Zou d, Koichiro Harada a, Masaki Shimoyama a, Yasushi Imai a, Koshiro Monzen a, b, Tsutomu Yamazaki a, c, Yoshio Yazaki e, Ryozo Nagai a, Issei Komuro d</span></span></div>
<div class="aff">
<h3 class="label" style="background-color: white; color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<ul class="affiliation" style="border: 0px; color: #5c5c5c; font-family: 'Arial Unicode MS', 'Arial Unicode', Arial, 'URW Gothic L', Helvetica, Tahoma, sans-serif; font-size: 0.8em; line-height: 20px; list-style: none; margin: 0px 0px 6px; padding: 0px; vertical-align: baseline;">
<li id="aff1" style="border: 0px; display: block; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;"><sup style="border: 0px; font-size: 0.75em; line-height: 0; margin: 0px; padding: 0px;">a</sup> <span id="" style="border: 0px; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;">Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan</span></li>
<li id="aff2" style="border: 0px; display: block; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;"><sup style="border: 0px; font-size: 0.75em; line-height: 0; margin: 0px; padding: 0px;">b</sup> <span id="" style="border: 0px; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;">Department of Pharmacoepidemiology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan</span></li>
<li id="aff4" style="border: 0px; display: block; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;"><sup style="border: 0px; font-size: 0.75em; line-height: 0; margin: 0px; padding: 0px;">c</sup> <span id="" style="border: 0px; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;">Department of Clinical Bioinformatics, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan</span></li>
<li id="aff3" style="border: 0px; display: block; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;"><sup style="border: 0px; font-size: 0.75em; line-height: 0; margin: 0px; padding: 0px;">d</sup> <span id="" style="border: 0px; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;">Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan</span></li>
<li id="aff5" style="border: 0px; display: block; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;"><sup style="border: 0px; font-size: 0.75em; line-height: 0; margin: 0px; padding: 0px;">e</sup> <span id="" style="border: 0px; font-size: 10.909090995788574px; margin: 0px; padding: 0px; vertical-align: baseline;">International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan</span></li>
</ul>
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/15313208">http://www.ncbi.nlm.nih.gov/pubmed/15313208</a><br />
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<div style="font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<hr style="color: #666666; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="color: #666666; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.600000381469727px; line-height: 14.399999618530273px; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
<div style="font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
<div style="background-color: white; color: #666666; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13px; line-height: 18px; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<b><span style="background-color: #f3f3f3; font-family: Calibri, sans-serif; font-size: 17.77777862548828px; line-height: 20px;">Fig. 2A</span><span class="apple-converted-space" style="font-family: Calibri, sans-serif; font-size: 17.77777862548828px; line-height: 20px;"> </span></b></div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span class="apple-converted-space" style="background-color: #f3f3f3; line-height: 20px;"><span style="font-family: Arial, Helvetica, sans-serif;"><b><span style="line-height: 18px;">c-fos</span><span lang="JA" style="line-height: 18px;">の</span><span style="line-height: 18px;">ANP</span><span lang="JA" style="line-height: 18px;">と</span><span style="line-height: 18px;">8-Bromo</span><span lang="JA" style="line-height: 18px;">のバンドも左右反転して横にちょっと拡大?</span></b></span></span></div>
<div class="separator" style="clear: both; line-height: 1.0915em; text-align: center;">
</div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhqBx4NxkOzfQUVkqNrzzrpRfpzovNDd8qXNrTSJXOI2sFWXqjYoQLvgFFPEfVbHFhgaiv1LcOALYNhrLnN5oQmvWHDixsqo2LjtfaH3J8YaQBhtdge2eLnuJ-jYJddzTISGXPwR6yyXoHr/s1600/concern+%231.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhqBx4NxkOzfQUVkqNrzzrpRfpzovNDd8qXNrTSJXOI2sFWXqjYoQLvgFFPEfVbHFhgaiv1LcOALYNhrLnN5oQmvWHDixsqo2LjtfaH3J8YaQBhtdge2eLnuJ-jYJddzTISGXPwR6yyXoHr/s400/concern+%231.jpg" height="310" width="400" /></a></div>
<br />
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<hr style="color: #666666; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="color: #666666; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.600000381469727px; line-height: 14.399999618530273px; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<b><span style="background-color: #f3f3f3; font-family: Calibri, sans-serif; font-size: 17.77777862548828px; line-height: 20px;">Fig. 2A</span></b></div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<b><span class="apple-converted-space" style="background-color: #f3f3f3; line-height: 20px;"><span style="font-family: Arial, Helvetica, sans-serif;">18SのANPと8-Bromoのバンドが類似: 横にちょっと拡大?</span></span></b></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgE61fS_79bf5L1t8xn5iO82xDnoZbfN7iQlkwsCTvMiCXd7JZEysPqtJLXT8_EzcV2RN4CR6ryUEmRd4Ew6ODuviCntiHFd5ASSwfGQCeXxq3ylDqSX93DbQe98WGeHKb0VufPLlGT_zIY/s1600/concern+%232.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgE61fS_79bf5L1t8xn5iO82xDnoZbfN7iQlkwsCTvMiCXd7JZEysPqtJLXT8_EzcV2RN4CR6ryUEmRd4Ew6ODuviCntiHFd5ASSwfGQCeXxq3ylDqSX93DbQe98WGeHKb0VufPLlGT_zIY/s400/concern+%232.jpg" height="310" width="400" /></a></div>
<b><span class="apple-converted-space" style="font-family: Calibri, sans-serif; font-size: 17.77777862548828px; line-height: 20px;"><br /></span></b></div>
<div class="separator" style="clear: both; line-height: 1.0915em; text-align: center;">
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
<hr style="color: #666666; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="color: #666666; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.600000381469727px; line-height: 14.399999618530273px; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
<div style="font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
<div style="color: #666666; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13px; line-height: 18px; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="background-color: #f3f3f3; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><b>Fig. 2B<span class="apple-converted-space"> </span></b></span><span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><span style="background-color: #f3f3f3;"><b><br />28S Line 1 = 28S Line 4<br />28S Line 2 = 28S Line 5<span class="apple-converted-space"> </span><br />28S Line 3 = 28S Line 6<span class="apple-converted-space"> </span></b></span></span></div>
<div class="separator" style="clear: both; line-height: 1.0915em; text-align: center;">
</div>
<div style="line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjoiqFvK2AjQGEMnRZ2DisL1WlsKiU1ngN_DGYMWotHxm1UtfiQ76-GotJhbwWSyxV2tAlutBBjgbbsl7Ip1W-PslpwmHYT2gM_DLWWtF1khTRhgbYkV8t9yO41_OHA3Dys7sBMPURtWbcX/s1600/concern+%233.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjoiqFvK2AjQGEMnRZ2DisL1WlsKiU1ngN_DGYMWotHxm1UtfiQ76-GotJhbwWSyxV2tAlutBBjgbbsl7Ip1W-PslpwmHYT2gM_DLWWtF1khTRhgbYkV8t9yO41_OHA3Dys7sBMPURtWbcX/s400/concern+%233.jpg" height="237" width="400" /></a></div>
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-59476889090353220132013-05-07T19:00:00.001+09:002013-05-12T17:39:19.606+09:00Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.<a href="http://isseikomuro.blogspot.com/2013/05/nat-cell-biol-2004-jun66499-506.html" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"><span role="menubar">Nat Cell Biol.</span> 2004 Jun;6(6):499-506.</a><span style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"> Epub 2004 May 16.</span><br />
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.</h1>
<div>
Yunzeng Zou 1, Hiroshi Akazawa 1, Yingjie Qin 1, Masanori Sano 1, Hiroyuki Takano 1, Tohru Minamino 1, Noriko Makita 2, Koji Iwanaga 1, Weidong Zhu 1, Sumiyo Kudoh 3, Haruhiro Toko 1, Koichi Tamur a4, Minoru Kihara 4, Toshio Nagai 1, Akiyoshi Fukamizu 5, Satoshi Umemura 4, Taroh Iiri 2, Toshiro Fujita 2 & Issei Komuro 1</div>
<div class="aff">
<h3 class="label" style="background-color: white; color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/15146194">http://www.ncbi.nlm.nih.gov/pubmed/15146194</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.nature.com/ncb/journal/v6/n6/full/ncb1137.html">http://www.nature.com/ncb/journal/v6/n6/full/ncb1137.html</a></div>
<div style="background-color: white; margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="text-align: center;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;"><b>ACKNOWLEDGEMENTS</b></span></span></div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;">We thank R. J. Lefkowitz, J. Sadoshima and S. Kimura for plasmids; S.-i. </span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">Miura for advice; and A. Okubo, E. Fujita, R. Kobayashi and M.Watanabe for </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">technical support. This work was supported by a Grant-in-Aid for Scientific </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">Research, Developmental Scientific Research, and Scientific Research on</span><br />
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;">Priority Areas from the Ministry of Education, Science, Sports, and Culture; </span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">and by a grant for research on life science from Uehara Memorial </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">Foundation, Japan (to I.K.).</span><br />
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;"><br /></span></span>
<br />
<div style="text-align: right;">
<div style="text-align: center;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;"><b>COMPETING FINANCIAL INTERESTS</b></span></span></div>
</div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;">The authors declare that they have no competing financial interests.</span></span></div>
<hr style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;" />
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="line-height: 1.0915em;">
<span style="font-family: Arial, Helvetica, sans-serif;"><b style="background-color: #f3f3f3;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 2e</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">上段左から三つ目と</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 3e</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">左から二つ目が類似</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">?<span class="apple-converted-space"> </span></span></b></span></div>
<br />
<br />
<br />
<div class="separator" style="clear: both; line-height: 1.0915em; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiL-RJBsx95532Mo_rln4ZtsHtRIRgFig-nodNwxL_adElF6miUWQq-30NZBvrcFGGxWtEY8t-BOIo2WtM_CBDKf35-WxkUU2rO_MbqFWyGf1PuRtOaZhJ-6kK9GynlzC7Ox3_KyGYKS671/s1600/Fig+2e+3e+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="287" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiL-RJBsx95532Mo_rln4ZtsHtRIRgFig-nodNwxL_adElF6miUWQq-30NZBvrcFGGxWtEY8t-BOIo2WtM_CBDKf35-WxkUU2rO_MbqFWyGf1PuRtOaZhJ-6kK9GynlzC7Ox3_KyGYKS671/s400/Fig+2e+3e+copy.jpg" width="400" /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span style="font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
<br />
<br />
<br />
<br />
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<hr />
<br />
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
</div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<br />
<div style="line-height: 1.0915em;">
<b><span style="background-color: #f3f3f3; font-family: Arial, Helvetica, sans-serif;"><span style="line-height: 18px;">Fig. 2f</span><span lang="JA" style="line-height: 18px;">下段の右端と</span><span style="line-height: 18px;">Fig. 2h</span><span lang="JA" style="line-height: 18px;">の右端が類似。</span><span class="apple-converted-space"><span style="line-height: 18px;"> </span></span></span></b></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<span class="apple-converted-space"><br /></span></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj7pICctQwXUe_f29d6J3PXe8ecBezFnu6eohCRESrhFP0QLmLJYBUGJou70HOy848cn8muE4qlmcvaOObuacHtabt7MpPWt7vHnEG5YqfbzVeIVksLzju2JuTvOANXOgUgye0TyScWV2I5/s1600/Fig+2f+2h+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="290" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj7pICctQwXUe_f29d6J3PXe8ecBezFnu6eohCRESrhFP0QLmLJYBUGJou70HOy848cn8muE4qlmcvaOObuacHtabt7MpPWt7vHnEG5YqfbzVeIVksLzju2JuTvOANXOgUgye0TyScWV2I5/s400/Fig+2f+2h+copy.jpg" width="400" /></a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
</div>
</div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<hr />
<br />
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
</div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-9723229724327707442013-05-07T18:58:00.004+09:002013-05-12T17:45:21.937+09:00Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury.<br />
<br />
<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<a href="http://isseikomuro.blogspot.com/2013/05/circulation-2003-dec-16108243024-30.html"><span role="menubar">Circulation.</span> 2003 Dec 16;108(24):3024-30.</a> Epub 2003 Nov 17.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15px;">Yunzeng Zou, MD, PhD*; Weidong Zhu, MD, PhD*; Masaya Sakamoto, MD; Yingjie Qin, MD; Hiroshi Akazawa, MD; Haruhiro Toko, MD, PhD; Miho Mizukami, MD; Norihiko Takeda, MD; Tohru Minamino, MD, PhD; Hiroyuki Takano, MD, PhD; Toshio Nagai, MD, PhD; Akira Nakai, MD, PhD; Issei Komuro, MD, PhD</span></span></div>
<div class="aff">
<h3 class="label" style="background-color: white; color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
Department of Cardiovascular Science and Medicine, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. komuro-tky@umin.ac.jp</div>
<div style="background-color: white; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14px; line-height: 17.453125px;">From the Department of Cardiovascular Science and Medicine (Y.Z., W.Z., M.S., Y.Q., H.A., H.T., M.M., T.M., H.T., T.N., I.K.), Chiba University Graduate School of Medicine, Chiba; Department of Cardiovascular Medicine (N.T.), University of Tokyo Graduate School of Medicine, Tokyo; and Department of Bio-Signal Analysis, Applied Medical Engineering Science (A.N.), Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.</span></span></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/14623809">http://www.ncbi.nlm.nih.gov/pubmed/14623809</a></div>
<div style="background-color: white; margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<a href="http://circ.ahajournals.org/content/108/24/3024.long">http://circ.ahajournals.org/content/108/24/3024.long</a></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em;">
<br /></div>
<br />
<div style="text-align: center;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;"><b>Acknowledgments</b></span></span></div>
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;">This work was supported by a Grant-in-Aid for Scientific Research, </span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">Developmental Scientific Research, and Scientific Research on </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">Priority Areas from the Ministry of Education, Science, Sports, and</span><br />
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;">Culture and by a grant for research on life science from Uehara </span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">Memorial Foundation, Japan (to I. Komuro).</span><br />
</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<hr style="background-color: white; color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 14.541666984558105px;" />
<div style="line-height: 14.541666984558105px;">
<span style="font-family: Arial, Helvetica, sans-serif; font-size: large;"><b style="background-color: #f3f3f3;"><span style="background: #EFEFEF; color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">Fig. 5c Sham TG</span><span lang="JA" style="background: #EFEFEF; color: black; font-family: "MS Mincho"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin;">と</span><span style="background: #EFEFEF; color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">I/R TG</span><span lang="JA" style="background: #EFEFEF; color: black; font-family: "MS Mincho"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin;">の上部のバンドが類似?</span><span class="apple-converted-space"><span style="background: #EFEFEF; color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"> </span></span></b></span></div>
<div style="background-color: white; color: #666666; line-height: 14.541666984558105px;">
<span class="apple-converted-space"><br /></span>
<br />
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em;">
<span class="apple-converted-space"><br /></span></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em;">
<span class="apple-converted-space"><br /></span></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiUuynHtOeQgahJ_8XYM_sE60knyltkDodCuomlmw8ceUazEj9UJccfHKtRnrxW6QhP_l6A6Bq5XFYpTWxYOoDRGv5nAzlkvnBEngRnrfVVxRl3ITBVPLk9LnLMylfj-9Q0CARhHtVmryiN/s1600/Circulation+2003+Fig5.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiUuynHtOeQgahJ_8XYM_sE60knyltkDodCuomlmw8ceUazEj9UJccfHKtRnrxW6QhP_l6A6Bq5XFYpTWxYOoDRGv5nAzlkvnBEngRnrfVVxRl3ITBVPLk9LnLMylfj-9Q0CARhHtVmryiN/s640/Circulation+2003+Fig5.jpg" width="391" /></a></div>
<span class="apple-converted-space"><br /></span></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em;">
<span class="apple-converted-space"><br /></span></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em;">
<span class="apple-converted-space"><br /></span>
<span class="apple-converted-space"><br /></span></div>
<div style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em;">
<span class="apple-converted-space"><span style="background: #EFEFEF; color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"></span></span></div>
<hr style="font-size: 0.8465em; line-height: 14.541666984558105px;" />
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-10094033948156965462013-05-07T18:57:00.004+09:002013-05-10T17:07:13.747+09:00Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.<br />
<br />
<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<a href="http://isseikomuro.blogspot.com/2013/05/circulation-2002-mar-12105101240-6.html"><span role="menubar"><span class="highlight">Circulation</span>.</span> <span class="highlight">2002</span> Mar 12;<span class="highlight">105</span>(<span class="highlight">10</span>):<span class="highlight">1240-6</span>.</a></div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px;">Asakawa M, Takano H, Nagai T, Uozumi H, Hasegawa H, Kubota N, Saito T, Masuda Y, Kadowaki T, Komuro I.</span></span></div>
<div class="aff">
<h3 class="label" style="background-color: white; color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/11889020">http://www.ncbi.nlm.nih.gov/pubmed/11889020</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://circ.ahajournals.org/content/105/10/1240.long">http://circ.ahajournals.org/content/105/10/1240.long</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br />
高解像度のHTML版(有料契約経路)から画像をダウンロードして比較してください(無料版は画像がダウンロードできなくなっているようです)。</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
PDF版は低解像度ですので類似性を比較するのは難しいです。<br />
<br /></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
</div>
<hr style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 14.541666984558105px;" />
<div>
<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #eeeeee; line-height: 14.541666984558105px;"><b>Fig1A</b></span></span><b style="background-color: white; font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 14.541666984558105px;"> Skeletal alpha-actin 右から1-3列とFig1B Skeletal alpha-actin 右から2-4列が類似?</b></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgcYMo-TJgOYhCSqGADP8SyjCyL_Xh2BYVHoxtWF5ml4fCBsp2rF5Oz8RkXy6coWwzYjUIMzQ8uGeVNAWsoPDm6BRHzGxUdzeAz9xCgzc45TFKDeU7pgu0iPOhsNWmJrWxK-chStU15YqMt/s1600/Fig1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="349" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgcYMo-TJgOYhCSqGADP8SyjCyL_Xh2BYVHoxtWF5ml4fCBsp2rF5Oz8RkXy6coWwzYjUIMzQ8uGeVNAWsoPDm6BRHzGxUdzeAz9xCgzc45TFKDeU7pgu0iPOhsNWmJrWxK-chStU15YqMt/s400/Fig1.jpg" width="400" /></a></div>
<span style="color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"><br /></span></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiWBsl1IkcA1rN0WU8DfjNNmukx4BcUlvjxt_EP5OHPqaVmyrvbEyLHsC3X7jnlMEjCyN2oiqVvIVYUOpF86Xj9Rz8M0xWJaQIDwerSC8Nu_4zw7ebYHQtlU2T0-yzc2mL63tzeeQxms19n/s1600/Fig1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><span style="color: black;"></span></a></div>
<span style="color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"><br /></span></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<br /></div>
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<hr style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 14.541666984558105px;" />
</div>
</div>
<div>
<span style="background-color: #eeeeee; line-height: 14.53125px;"><b><span style="font-family: Arial, Helvetica, sans-serif;">Fig1 A</span></b></span><b style="background-color: white; font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="line-height: 14.53125px;"><span style="font-family: Arial, Helvetica, sans-serif;"> ANPの左から2-4レーンとFig1 B ANP 左から5-7レーンが類似?</span></b></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<span style="color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"><br /></span></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhmlcAUy_QLdf07uAOm9vj2lOC18fkKa_rW9c7HpEBm5ujGNucQSiwnoEnXE11gmdVb2mgxVrvvCze8ODf3DIlFgUv3cDRrPyKs3TAGuf4ZJ80_dbs0cDuAYC58WQp4mUDsu5Pbwo8yBnf2/s1600/Fig1+2.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><span style="color: black;"></span></a></div>
<span style="color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"><br /></span></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiPNfwYc1iT2Mr1VbyUzDyWOl740Lh8BdQRMvXj470XEoSt-KdBj7wOzfx9Akkys2-RZSoSqtMUfwz6FpdqdpWlsdMcfYLfyIYPwBmOCpmSkxQxkQUejhFXH8_xWYW_24vbNrhb5BVxcSWc/s1600/Fig1-2.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="383" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiPNfwYc1iT2Mr1VbyUzDyWOl740Lh8BdQRMvXj470XEoSt-KdBj7wOzfx9Akkys2-RZSoSqtMUfwz6FpdqdpWlsdMcfYLfyIYPwBmOCpmSkxQxkQUejhFXH8_xWYW_24vbNrhb5BVxcSWc/s400/Fig1-2.jpg" width="400" /></a></div>
<span style="font-family: Arial, Helvetica, sans-serif; font-size: medium;"><b style="background-color: #f3f3f3;"><span style="background-color: #efefef; color: black; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 21.33333396911621px;"><br /></span></b></span></div>
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<br /></div>
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<hr style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 14.541666984558105px;" />
</div>
</div>
<div>
<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #eeeeee; line-height: 14.53125px;"><b>Fig1 A</b></span></span><b style="background-color: white; font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 14.53125px;"> 18S 1-4レーンとFog1B 18S 左1-4が類似?</b></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjQuyBpYwOaIEaRZdrOPMZGh36aMS_zUHqVXv_lv7y7pdX_CpJvPWpzldqF3ebqDVmIa3JD5HSgRJJlMncfVNqk5WuS9BE9lgW-1pnr-7_5oZ-JmdmfPAKhCuosC7B5_9_oYw5eU7Jyo2cm/s1600/Fig1-3.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="294" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjQuyBpYwOaIEaRZdrOPMZGh36aMS_zUHqVXv_lv7y7pdX_CpJvPWpzldqF3ebqDVmIa3JD5HSgRJJlMncfVNqk5WuS9BE9lgW-1pnr-7_5oZ-JmdmfPAKhCuosC7B5_9_oYw5eU7Jyo2cm/s400/Fig1-3.jpg" width="400" /></a></div>
<br />
<br />
<br /></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<br />
<br />
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<hr style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 14.541666984558105px;" />
</div>
</div>
<div style="font-family: 'MS PGothic'; font-size: medium; line-height: normal;">
</div>
</div>
</div>
<div style="background-color: white; line-height: 14.541666984558105px;">
<div style="line-height: 14.541666984558105px;">
<div style="line-height: normal;">
<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #eeeeee; line-height: 14.53125px;"><b>Fig1A</b></span></span><b style="font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 14.53125px;"> 18S 左から1レーン目と2レーン目が類似?</b><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #eeeeee; line-height: 14.53125px;"><b>Fig1A</b></span></span><b style="font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 14.53125px;"> 18S 左から3レーン目と4レーン目が類似?</b></div>
<div style="font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px;">
<br /></div>
<div style="font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px;">
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh9QJNoZZ9rrJqVe5P0t8N28y_W_lNzazjDshbNTlaL_k4qyDsjDxBfmhG19-UX1Bpfy9qpKIVhnuH_ATxkMcI-9OJKDWaxrVl0bOeL9-pa0i1vxmOS0cVUXw3abrvzI6HgSqalAj2dQMau/s1600/Fig1-4.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh9QJNoZZ9rrJqVe5P0t8N28y_W_lNzazjDshbNTlaL_k4qyDsjDxBfmhG19-UX1Bpfy9qpKIVhnuH_ATxkMcI-9OJKDWaxrVl0bOeL9-pa0i1vxmOS0cVUXw3abrvzI6HgSqalAj2dQMau/s400/Fig1-4.jpg" width="256" /></a></div>
<br /></div>
<div style="font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px;">
<br /></div>
<div style="font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px;">
<br /></div>
<hr style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 14.541666984558105px;" />
</div>
</div>
<div>
<div style="text-align: justify;">
<b><span style="color: #191919; font-family: Lucida Sans Unicode, Arial, Lucida Grande, Tahoma, Verdana, Helvetica, sans-serif;"><span style="line-height: 15.1875px;">この研究に用いられた化合物(医薬品の有効成分)には、</span></span><span style="background-color: white; color: #191919; font-family: 'Lucida Sans Unicode', Arial, 'Lucida Grande', Tahoma, Verdana, Helvetica, sans-serif; line-height: 15.1875px;">pioglitazone (ピオグリタゾン、糖尿病薬のアクトスの有効成分)などがあり、武田薬品工業などから無償で供与されている。</span></b></div>
<b><span style="background-color: white; color: #191919; font-family: 'Lucida Sans Unicode', Arial, 'Lucida Grande', Tahoma, Verdana, Helvetica, sans-serif; line-height: 15.199999809265137px; text-align: justify;"><br /></span>
<span style="background-color: white; color: #191919; font-family: 'Lucida Sans Unicode', Arial, 'Lucida Grande', Tahoma, Verdana, Helvetica, sans-serif; line-height: 15.199999809265137px; text-align: justify;">以下、論文のMethodsのMaterialsの文章より引用。</span></b><br />
<span style="background-color: white; color: #191919; font-family: 'Lucida Sans Unicode', Arial, 'Lucida Grande', Tahoma, Verdana, Helvetica, sans-serif; font-size: 12.800000190734863px; line-height: 15.199999809265137px; text-align: justify;"><br /></span>
<span style="background-color: white; color: #191919; font-family: 'Lucida Sans Unicode', Arial, 'Lucida Grande', Tahoma, Verdana, Helvetica, sans-serif; font-size: 12.800000190734863px; line-height: 15.199999809265137px; text-align: justify;">Troglitazone, pioglitazone, and rosiglitazone were generous gifts from Sankyo Co, Takeda Co, and SmithKline Beecham, respectively. </span></div>
<div style="background-color: white; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<br />
<br />
<br />
<div style="font-family: 'MS PGothic'; font-size: medium;">
<div style="font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px;">
<br /></div>
<hr style="font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em;" />
</div>
<div style="font-family: 'MS PGothic'; font-size: medium; line-height: normal;">
</div>
</div>
<div style="background-color: white; color: #666666; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
</div>
</div>
</div>
<br />
<div class="aff" style="background-color: white;">
<div style="color: #666666; font-family: 'Trebuchet MS', Trebuchet, Verdana, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
<div style="font-size: 13.333333015441895px; line-height: 14.541666984558105px;">
</div>
</div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-2127504660981560327.post-34897288482300635412013-05-07T18:46:00.001+09:002013-05-12T17:59:25.740+09:00Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.<a href="http://isseikomuro.blogspot.com/2013/05/j-biol-chem-1999-mar-19274128231-9.html" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"><span role="menubar">J Biol Chem.</span> 1999 Mar 19;274(12):8231-9.</a><br />
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Context-dependent transcriptional cooperation mediated by <span class="highlight">cardiac</span> transcription factors Csx/Nkx-2.5 and GATA-4.</h1>
<div class="auths" style="background-color: white;">
<span style="font-family: Arial, Helvetica, sans-serif;">Ichiro Shiojima‡</span><span style="font-family: Arial, Helvetica, sans-serif;"> </span><span style="font-family: Arial, Helvetica, sans-serif;">(塩島一朗)</span><span style="font-family: Arial, Helvetica, sans-serif;">, Issei Komuro§<span style="color: #333333; font-weight: bold; line-height: 10.666666984558105px;"> </span><span style="color: #333333; font-style: inherit; line-height: 1.7;">(</span><a href="http://komuroissei.blogspot.com/" style="font-style: inherit; line-height: 1.7;">小室一成</a><span style="color: #333333; font-style: inherit; line-height: 1.7;">)</span>, Toru Oka (岡 亨), Yukio Hiroi(広井 透雄), Takehiko Mizuno (水野 健彦), Eiki Takimoto (瀧本 英樹), Koshiro Monzen (門前 幸志郎), Ryuichi Aikawa</span><span style="color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: 1.7;">(相川 竜一)</span><span style="font-family: Arial, Helvetica, sans-serif;">, Hiroshi Akazawa (赤澤 宏), Tsutomu Yamazaki (山崎 力)</span><span style="font-family: Arial, Helvetica, sans-serif;">, Sumiyo Kudoh </span><span style="color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: 1.7;">(久藤 純代) </span><span style="font-family: Arial, Helvetica, sans-serif;">and Yoshio Yazaki</span><span style="color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: 1.7;"> </span><span style="color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: 1.7;">(矢崎 義雄)</span></div>
<div class="aff">
<h3 class="label" style="background-color: white; color: #724128; font-family: arial, helvetica, clean, sans-serif; font-size: 1.0769em; height: 1px; left: -10000px; line-height: 1.2857; margin: 1.2856em 0px 0.6428em; overflow: hidden; position: absolute; top: auto; width: 1px;">
Source</h3>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.</div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/10075728" style="font-size: 0.8465em; line-height: 1.0915em;">http://www.ncbi.nlm.nih.gov/pubmed/10075728</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.jbc.org/content/274/12/8231.long">http://www.jbc.org/content/274/12/8231.long</a></div>
<div style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.0915em; margin-bottom: 0.5em; margin-top: 0.5em;">
<br /></div>
<div style="background-color: white; margin-bottom: 0.5em; margin-top: 0.5em;">
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;">* This work was supported in part by grants from the Japanese </span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">Ministry of Education, Science, and Culture; the Japan Heart Foundation; </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">Yamanouchi Pharmaceuticals; and Tanabe Medical Frontier Conference. </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">The costs of publication of this article were defrayed in part by </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;">the payment of page charges. This article must therefore be hereby </span></span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">marked “advertisement” in accordance with 18 U.S.C. Section 1734 </span><span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">solely to indicate this fact.</span><br />
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small; line-height: 14.770833015441895px;">‡ Supported by the Sankyo Foundation of Life Science.</span><br />
<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 14.770833015441895px;"><br /></span></span>
<br />
<div>
<br /></div>
<hr style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;" />
<div class="content clearfix" style="color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px; position: relative; word-wrap: break-word;">
</div>
<div>
<span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 2B TTF1</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">と</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 2C NKE2</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">が類似?</span><span class="apple-converted-space" style="background-color: #eeeeee; font-family: Arial, Helvetica, sans-serif; line-height: 1.0915em;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span></div>
<br /></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<div style="line-height: 1.0915em;">
<span style="background-color: #eeeeee;"><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">上部右のドット状のノイズに着目</span><span class="apple-converted-space"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span><span style="line-height: 18px;"><br /><span style="background-position: initial initial; background-repeat: initial initial;">Fig. 2B</span></span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">は右のレーンとつなぎ合わせた痕跡を下部に感じる</span><span class="apple-converted-space"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span></span></span></div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiE-LVQ_PmGyXILBAaU7pzQxZfZdvC7p9HU6Fcx7foWjJFsJraO5eTLdrLlsTCo_o5y4izPLeij0zsqBYPtLobQfbERDKxq3UarokpFv6pekpEpQxLsA2ZsPRh8ZCR1I5BQ9gFegHfOGrmJ/s1600/Fig2.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiE-LVQ_PmGyXILBAaU7pzQxZfZdvC7p9HU6Fcx7foWjJFsJraO5eTLdrLlsTCo_o5y4izPLeij0zsqBYPtLobQfbERDKxq3UarokpFv6pekpEpQxLsA2ZsPRh8ZCR1I5BQ9gFegHfOGrmJ/s400/Fig2.jpg" width="226" /></a></div>
<div style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px; line-height: 16.375749588012695px;"><br /></span></span><span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px; line-height: 16.375749588012695px;"><br /></span></span></div>
<div class="separator" style="background-color: white; clear: both; text-align: center;">
</div>
<div class="separator" style="background-color: white; clear: both; text-align: center;">
</div>
<div style="background-color: white;">
<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px; line-height: 16.375749588012695px;"><br /></span></span><span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px; line-height: 16.375749588012695px;"><br /></span></span></div>
<div style="background-color: white;">
<br style="color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;" /></div>
<div style="background-color: white;">
<br /></div>
<hr style="background-color: white; color: #666666; font-family: arial, helvetica, clean, sans-serif; font-size: 13.333333015441895px; line-height: 14.541666984558105px;" />
<div class="content clearfix" style="background-color: white; color: #333333; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.44444465637207px; line-height: 17.98611068725586px; margin-left: 58px; position: relative; word-wrap: break-word;">
</div>
<div style="background-color: white;">
<br /></div>
<span style="background-color: white; font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px; line-height: 16.375749588012695px;"><br /></span></span><span style="background-color: white; font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px; line-height: 16.375749588012695px;"><br /></span></span><span style="background-color: white; font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px; line-height: 16.375749588012695px;"><br /></span></span><span style="background-color: #eeeeee;"><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">なお、</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 7</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">の左側の</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">CSX+ GATA-4+</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">のレーンにも上部右にドット状のノイズがあり、</span><span class="apple-converted-space" style="line-height: 1.0915em;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span><span style="line-height: 18px;"><br /></span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">左のレーンとつなぎ合わせた痕跡を下部や中央部に感じる</span><span class="apple-converted-space" style="line-height: 1.0915em;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span></span></span><span style="background-color: white; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 20px;"><br /></span></div>
</div>
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0