Cell. 2012 Jun 8;149(6):1298-313. doi: 10.1016/j.cell.2012.03.047.
Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A,Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.
Source
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan.
Erratum in http://www.cell.com/retrieve/pii/S009286741200877X
The article above reported a role for complement C1q in promoting age-related phenotypes. Since publication, we have noticed that the upper panels shown inFigure 7F were incorrectly selected and labeled. The upper-right panel portrayed an image from aged C1qKO mice, not aged wild-type mice treated with M241, as originally labeled. The upper-left panel was correctly labeled as aged wild-type mice treated with PBS, but the magnification of both images in the top panels was incorrectly labeled and did not match the magnification of the bottom two panels. The corrected figure, with the upper-left panel now portraying an image from aged wild-type mice treated with PBS and the upper-right panel portraying an image from aged wild-type mice treated with M241, both taken with a 4× magnification (scale bars, 150 μm), is shown on the following page. We sincerely apologize for these mistakes and emphasize that the correction of these errors does not impact our conclusions
不適切に使用されていた実験画像は、サイズ変更だけでなく縦横比も変更されていたことが判明。意図的な改ざんか？という疑惑を晴らすためには生データの確認が必要。
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