2013年5月7日火曜日

Mitochondrial DNA that escapes from autophagy causes inflammationand heart failure.



Nature. 2012 May 10;485(7397):251-5. doi: 10.1038/nature10992.

Mitochondrial DNA that escapes from autophagy causes inflammationand heart failure.

Takafumi Oka 1 (岡崇史) , Shungo Hikoso 1 (彦惣俊吾), Osamu Yamaguchi 1 (山口修), Manabu Taneike 1,2(種池学), Toshihiro Takeda 1 (武田理宏) , Takahito Tamai 1 (玉井敬人), Jota Oyabu 1 (大藪丈太), Tomokazu Murakawa 1 (村川智), Hiroyuki Nakayama 3 (中山博之), Kazuhiko Nishida 1,2(西田和彦), Shizuo Akira 4,5 (審良静男), Akitsugu Yamamoto 6 (山本章嗣) , Issei Komuro 1 (小室一成)& Kinya Otsu 1,2 (大津 欣也)

Source

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

Fig. 4d
































大阪大学大学院医学系研究科 循環器内科学 Nature誌論文 Fig.4d 最下段(CD3)の一番左の画像が、上から3段目(Ly6G)の一番右の画像と同一。 ケアレスミスか?念のため、他にも調査の必要性があるか?

 (その後、Corrigendum が出される。指摘の件以外にも、多数の不適切な画像操作が判明)
↓ 

Erratum in


Nature. 2012 Oct 11;490(7419):292.


In this Letter, several images were mistakenly switched or duplicated during preparation of the artwork. In Figs 1f and 2a, the sham-operated Dnase2a−/− and TAC-operated Dnase2a+/+ mice panels were switched. In Fig. 4d, the panel showing CD3 staining for ODN2088 control-treated TAC-operated Dnase2a+/+ mice (now shown correctly as black-bordered panel in Fig. 1 below) is a duplicate of that showing Ly6G staining for ODN2088-treated TAC-operated Dnase2a−/− mice. The panel showing CD45 staining for ODN2088-treated TAC-operated Dnase2a+/+ (now shown correctly as blue-bordered panel in Fig. 1 below) was prepared from the original picture of ODN2088 control-treated TAC-operated Dnase2a+/+. In Supplementary Fig. 4c, sham-operatedDnase2a−/− and TAC-operated Dnase2a+/+ mice panels were switched. Finally, in Supplementary Fig. 10d, the panels showing CD3 and Ly6G staining for sham-operated Tlr9+/+ mice were switched. These corrections do not alter any of the conclusions of this Letter, and the authors apologize for any confusion these errors may have caused.

大阪大学医学系グループが不適切研究! (ブログ 世界変動展望)



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