Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.
Yunzeng Zou 1, Hiroshi Akazawa 1, Yingjie Qin 1, Masanori Sano 1, Hiroyuki Takano 1, Tohru Minamino 1, Noriko Makita 2, Koji Iwanaga 1, Weidong Zhu 1, Sumiyo Kudoh 3, Haruhiro Toko 1, Koichi Tamur a4, Minoru Kihara 4, Toshio Nagai 1, Akiyoshi Fukamizu 5, Satoshi Umemura 4, Taroh Iiri 2, Toshiro Fujita 2 & Issei Komuro 1
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
ACKNOWLEDGEMENTSWe thank R. J. Lefkowitz, J. Sadoshima and S. Kimura for plasmids; S.-i. Miura for advice; and A. Okubo, E. Fujita, R. Kobayashi and M.Watanabe for technical support. This work was supported by a Grant-in-Aid for Scientific Research, Developmental Scientific Research, and Scientific Research on
Priority Areas from the Ministry of Education, Science, Sports, and Culture; and by a grant for research on life science from Uehara Memorial Foundation, Japan (to I.K.).
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